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Details for Product No. ABIN350138

Calcium Channel, Voltage-Dependent, L Type, alpha 1D Subunit (CACNA1D) (Cytoplasmic Domain) antibody

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Antigen
Synonyms CACH3, CACN4, CACNL1A2, CCHL1A2, Cav1.3, SANDD, C79217, Cchl1a, D-LTCC, Cchl1a2, Cacnl1a2, 8430418G19Rik, cacna1d, cav1.3a, isl, si:dz136d19.3, si:dz223c6.1, ca(v)1.3, cav1.3
Epitope
»Alternatives Cytoplasmic Domain
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350138
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from the a cytoplasmic domain of human CACNA1D (Cav1.3) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen shares 98% identity with mouse and rat sequence.
Specificity Appears to be specific for CACNA1D.
Purity whole serum
Alternative Name CACNA1D (Cav1.3)
Background Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in pancreatic islets and in brain, where it has been seen in hippocampus, basal ganglia, habenula and thalamus. No expression in skeletal muscle. Also known as: Voltage-dependent L-type calcium channel subunit alpha-1D, Voltage-gated calcium channel subunit alpha Cav1.3, Calcium channel, L type, alpha-1 polypeptide, CACH3, CACN4, CACNL1A2, CCHL1A2, Cav3.1.
UniProt Q01668
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Williams, Feldman, McCue et al.: "Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype." in: Neuron, Vol. 8, Issue 1, pp. 71-84, 1992 (PubMed).

Seino, Chen, Seino et al.: "Cloning of the alpha 1 subunit of a voltage-dependent calcium channel expressed in pancreatic beta cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 2, pp. 584-8, 1992 (PubMed).

Kamp, Mitas, Fields et al.: "Transcriptional regulation of the neuronal L-type calcium channel alpha 1D subunit gene." in: Cellular and molecular neurobiology, Vol. 15, Issue 3, pp. 307-26, 1995 (PubMed).

Yamada, Masuda, Li et al.: "The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genes." in: Genomics, Vol. 27, Issue 2, pp. 312-9, 1995 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Alternatives for antigen "Calcium Channel, Voltage-Dependent, L Type, alpha 1D Subunit (CACNA1D)", type "Antibodies"
Hosts (21), (12)
Reactivities (28), (27), (23), (17), (17), (17)
Applications (19), (15), (10), (8), (7), (7), (6), (4), (4), (3), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (3), (2), (2), (1)
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