Add to Basket
|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Calcium Channel, Voltage-Dependent, L Type, alpha 1D Subunit (CACNA1D) (Cytoplasmic Domain) antibody
|Synonyms||CACH3, CACN4, Cav1.3, CCHL1A2, CACNL1A2, C79217, Cchl1a, D-LTCC, Cchl1a2, Cacnl1a2, 8430418G19Rik, isl, cav1.3a, si:dz223c6.1, si:dz136d19.3, cav1.3, ca(v)1.3, MGC146469|
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
|5 references available|
|Quantity||100 µl (Variants)|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Alternative name||CACNA1D (Cav1.3)|
|Immunogen||A synthetic peptide from the a cytoplasmic domain of human CACNA1D (Cav1.3) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen shares 98% identity with mouse and rat sequence.|
|Description||Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Subcellular location: Membrane; Multi-pass membrane protein. Tissue specificity: Expressed in pancreatic islets and in brain, where it has been seen in hippocampus, basal ganglia, habenula and thalamus. No expression in skeletal muscle. Also known as: Voltage-dependent L-type calcium channel subunit alpha-1D, Voltage-gated calcium channel subunit alpha Cav1.3, Calcium channel, L type, alpha-1 polypeptide, CACH3, CACN4, CACNL1A2, CCHL1A2, Cav3.1.|
|Specificity||Appears to be specific for CACNA1D.|
|Application Notes||IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Williams, Feldman, McCue et al.: "Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype." in: Neuron, Vol. 8, Issue 1, pp. 71-84, 1992 (PubMed).
Seino, Chen, Seino et al.: "Cloning of the alpha 1 subunit of a voltage-dependent calcium channel expressed in pancreatic beta cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 2, pp. 584-8, 1992 (PubMed).
Kamp, Mitas, Fields et al.: "Transcriptional regulation of the neuronal L-type calcium channel alpha 1D subunit gene." in: Cellular and molecular neurobiology, Vol. 15, Issue 3, pp. 307-26, 1995 (PubMed).
Yamada, Masuda, Li et al.: "The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genes." in: Genomics, Vol. 27, Issue 2, pp. 312-9, 1995 (PubMed).
Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).
|Hosts||Rabbit (21), Mouse (11)|
|Reactivities||Rat (Rattus) (26), Human (25), Mouse (Murine) (24), Cow (Bovine) (19), Dog (Canine) (19), Horse (Equine) (19), Pig (Porcine) (19)|
|Applications||Immunofluorescence (IF) (18), Flow Cytometry (FACS) (16), Western Blotting (WB) (16), Immunoprecipitation (IP) (8), Immunocytochemistry (ICC) (6), Immunohistochemistry (IHC) (6), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (5), Immunostaining (ISt) (4), ELISA (3), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (Fixed) (IHC (fx)) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)|
|Conjugates||Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)|
|Epitopes||AA 859-875 (2), Cytoplasmic Domain (2), AA 2025-2161 (1)|