Calcium Channel, Voltage-Dependent, R Type, alpha 1E Subunit (CACNA1E) (C-Term) antibody

Antigen: Calcium Channel, Voltage-Dependent, R Type, alpha 1E Subunit (CACNA1E)

Synonyms: BII, CACH6, Cav2.3, CACNL1A6, CACHA1E, Cach6, Cchra1, alpha1E, Cacnl1a6, A430040I15, CACNA1E, caV2.3, LOC564274

Epitope: C-Term

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350140

Additional Information

Alternative name: CACNA1E (Cav2.3) (c-terminal region)

Swiss-Prot: Q15878

Immunogen: A synthetic peptide from c-terminal region of human CACNA1E (Cav2.3) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega-conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels contaning alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. Subcellular location: Membrane; Multi-pass membrane protein. Tissue specificity: Expressed in neuronal tissues and in kidney. Also known as: Voltage-dependent R-type calcium channel subunit alpha-1E, Voltage-gated calcium channel subunit alpha Cav2.3, Calcium channel, L type, alpha-1 polypeptide, Brain calcium channel II, CACH6, CACNL1A6.

Specificity: Appears to be specific for CACNA1E.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Schneider, Wei, Olcese et al.: "Molecular analysis and functional expression of the human type E neuronal Ca2+ channel alpha 1 subunit." in: Receptors & channels, Vol. 2, Issue 4, pp. 255-70, 1995 (PubMed).

Williams, Marubio, Deal et al.: "Structure and functional characterization of neuronal alpha 1E calcium channel subtypes." in: The Journal of biological chemistry, Vol. 269, Issue 35, pp. 22347-57, 1994 (PubMed).

Suzuki, Delgado-Escueta, Aguan et al.: "Mutations in EFHC1 cause juvenile myoclonic epilepsy." in: Nature genetics, Vol. 36, Issue 8, pp. 842-9, 2004 (PubMed).

Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).