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Calcium Channel, Voltage-Dependent, R Type, alpha 1E Subunit (CACNA1E) (C-Term) antibody

Details for Product No. ABIN350140, Supplier: Log in to see
Antigen
  • caV2.3
  • CACNA1E
  • BII
  • CACH6
  • CACNL1A6
  • Cav2.3
  • A430040I15
  • Cach6
  • Cacnl1a6
  • Cchra1
  • alpha1E
  • CACHA1E
Epitope
C-Term
2
1
1
1
1
Reactivity
Human, Rat (Rattus), Mouse (Murine)
26
22
20
2
Host
Rabbit
27
Clonality
Polyclonal
Conjugate
Un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
13
11
5
3
2
Supplier
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Immunogen A synthetic peptide from c-terminal region of human CACNA1E conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for CACNA1E.
Purification Whole serum
Alternative Name CACNA1E (CACNA1E Antibody Abstract)
Background Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega-conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels contaning alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in neuronal tissues and in kidney. Also known as: Voltage-dependent R-type calcium channel subunit alpha-1E, Voltage-gated calcium channel subunit alpha Cav2.3, Calcium channel, L type, alpha-1 polypeptide, Brain calcium channel II, CACH6, CACNL1A6.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user. Not tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1. ..." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

Suzuki, Delgado-Escueta, Aguan et al.: "Mutations in EFHC1 cause juvenile myoclonic epilepsy." in: Nature genetics, Vol. 36, Issue 8, pp. 842-9, 2004 (PubMed).

Williams, Marubio, Deal et al.: "Structure and functional characterization of neuronal alpha 1E calcium channel subtypes." in: The Journal of biological chemistry, Vol. 269, Issue 35, pp. 22347-57, 1994 (PubMed).

Schneider, Wei, Olcese et al.: "Molecular analysis and functional expression of the human type E neuronal Ca2+ channel alpha 1 subunit." in: Receptors & channels, Vol. 2, Issue 4, pp. 255-70, 1995 (PubMed).