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Calcium Channel, Voltage-Dependent, L Type, alpha 1F Subunit (CACNA1F) (AA 1700-1750) antibody

Details for Product No. ABIN350142
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Antigen
Synonyms AIED, COD3, COD4, CORDX, CORDX3, CSNB2, CSNB2A, CSNBX2, Cav1.4, Cav1.4alpha1, JM8, JMC8, OA2, A930034B14, Sfc17, nerg1, nob2, CACNA1F
Epitope
AA 1700-1750
(4), (1), (1)
Reactivity
Human
(24), (17), (17), (17), (17)
Host
Rabbit
(19), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(15), (14), (10), (8), (3), (1)
Pubmed 5 references available
Quantity 100 µL
Options
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Catalog No. ABIN350142
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A synthetic peptide from AA 1700-1750 of human CACNA1F conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for Olfactory receptors OR2C3.
Purification whole serum
Alternative Name CACNA1F (Cav1.4)
Background Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: Voltage-gated calcium channel subunit alpha Cav1.4, Voltage-dependent L-type calcium channel subunit alpha-1F, CACNAF1.
UniProt Q8N628
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Strom, Nyakatura, Apfelstedt-Sylla et al.: "An L-type calcium-channel gene mutated in incomplete X-linked congenital stationary night blindness." in: Nature genetics, Vol. 19, Issue 3, pp. 260-3, 1998 (PubMed).

Wutz, Sauer, Zrenner et al.: "Thirty distinct CACNA1F mutations in 33 families with incomplete type of XLCSNB and Cacna1f expression profiling in mouse retina." in: European journal of human genetics : EJHG, Vol. 10, Issue 8, pp. 449-56, 2002 (PubMed).

Ross, Grafham, Coffey et al.: "The DNA sequence of the human X chromosome...." in: Nature, Vol. 434, Issue 7031, pp. 325-37, 2005 (PubMed).

Hemara-Wahanui, Berjukow, Hope et al.: "A CACNA1F mutation identified in an X-linked retinal disorder shifts the voltage dependence of Cav1.4 channel activation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 21, pp. 7553-8, 2005 (PubMed).

Jalkanen, Bech-Hansen, Tobias et al.: "A novel CACNA1F gene mutation causes Aland Island eye disease." in: Investigative ophthalmology & visual science, Vol. 48, Issue 6, pp. 2498-502, 2007 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN350142
454.67 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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