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Details for Product No. ABIN350145

CACNA1HCACNA1G (Cav3.2, Cav3.1) (Cytoplasmic Domain) antibody

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Antigen
Epitope
»Alternatives Cytoplasmic Domain
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350145
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from a cytoplasmic domain of human CACNA1H & CACNA1G (Cav3.2, Cav3.1) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen shares 95% identity with the corresponding sequences in rat and mouse.
Isotype IgG
Specificity Appears to be specific for CACNA1H and CACNA1G.
Purity IgG
Background Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the low-voltage activated (LVA) group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.
Subcellular location: Membrane, Multi-pass membrane protein. Tissue specificity (CACNA1H): Expressed in kidney, liver, heart, brain. Isoform 2 seems to be testis-specific. Tissue specificity (CACNA1G): Highly expressed in brain, in particular in the amygdala, subthalamic nuclei, cerebellum and thalamus. Moderate expression in heart, low expression in placenta, kidney and lung. Also expressed in colon and bone marrow and in tumoral cells to a lesser extent. Highly expressed in fetal brain, but also in peripheral fetal tissues as heart, kidney and lung, suggesting a developmentally regulated expression. Also known as: Voltage-dependent T-type calcium channel subunit alpha-1H, Voltage-gated calcium channel subunit alpha Cav3.2, Low-voltage-activated calcium channel alpha1 3.2 subunit. Voltage-dependent T-type calcium channel subunit alpha-1G, Voltage-gated calcium channel subunit alpha Cav3.1, Cav3.1c, NBR13.
UniProt O95180
Application Notes IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not tested in other applications.
Restrictions For Research Use only
Cribbs, Lee, Yang et al.: "Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family." in: Circulation research, Vol. 83, Issue 1, pp. 103-9, 1998 (PubMed).

Williams, Washburn, Hans et al.: "Structure and functional characterization of a novel human low-voltage activated calcium channel." in: Journal of neurochemistry, Vol. 72, Issue 2, pp. 791-9, 1999 (PubMed).

Toyota, Ho, Ohe-Toyota et al.: "Inactivation of CACNA1G, a T-type calcium channel gene, by aberrant methylation of its 5' CpG island in human tumors." in: Cancer research, Vol. 59, Issue 18, pp. 4535-41, 1999 (PubMed).

Martin, Han, Gordon et al.: "The sequence and analysis of duplication-rich human chromosome 16." in: Nature, Vol. 432, Issue 7020, pp. 988-94, 2004 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Alternatives for antigen "CACNA1HCACNA1G (Cav3.2, Cav3.1)", type "Antibodies"
Hosts (1)
Applications (1), (1)
Epitopes (1)
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