Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1) (AA 100-150) antibody

Details for Product No. ABIN350149
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Antigen
Synonyms CACNA2D1, DKFZp469K2211, CACNA2, CACNL2A, CCHL2A, Ca(v)alpha2delta1, Cacna2, Cchl2a, CCHLA2, DHSCCA
Epitope
AA 100-150
(14), (5), (2), (2), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(51), (29), (28), (17), (15), (14), (3), (2), (1), (1)
Host
Rabbit
(45), (6), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(43), (22), (16), (10), (8), (7), (2), (2), (1), (1), (1)
Pubmed 4 references available
Quantity 100 μL
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Catalog No. ABIN350149
454.67 $
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Immunogen A synthetic peptide from aa region 100-150 of human CACNA2D1 conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for CACNA2D1.
Purification Whole serum
Alternative Name CACNA2D1
Background Function: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling.
Subcellular location: Membrane, Single-pass type I membrane protein
Tissue specificity: Central nervous system, skeletal muscle and aorta tissues.
Miscellaneous: Binds gabapentin, an antiepileptic drug. Also known as: Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-gated calcium channel subunit alpha-2/delta-1, CACNL2A, CCHL2A, MHS3.
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Williams, Feldman, McCue et al.: "Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype." in: Neuron, Vol. 8, Issue 1, pp. 71-84, 1992 (PubMed).

Jay, Sharp, Kahl et al.: "Structural characterization of the dihydropyridine-sensitive calcium channel alpha 2-subunit and the associated delta peptides." in: The Journal of biological chemistry, Vol. 266, Issue 5, pp. 3287-93, 1991 (PubMed).

Hamilton, Hawkes, Brush et al.: "Subunit composition of the purified dihydropyridine binding protein from skeletal muscle." in: Biochemistry, Vol. 28, Issue 19, pp. 7820-8, 1990 (PubMed).

Liu, Qian, Gritsenko et al.: "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." in: Journal of proteome research, Vol. 4, Issue 6, pp. 2070-80, 2005 (PubMed).

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