Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1) (N-Term) antibody

Antigen: Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1)

Synonyms: CACNA2, CCHL2A, CACNL2A, CACNA2D1, DKFZp469K2211

Epitope: N-Term

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350149

Additional Information

Alternative name: CACNA2D1 (CACNL2A) (n-terminal region)

Swiss-Prot: P54289

Immunogen: A synthetic peptide from the n-terminal region of human CACNA2D1 (CACNL2A) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is identical in rabbit and shares 90% identity with the corresponding sequences in mouse and rat.

Format: Lyophilized

Description: FUNCTION: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling. Subcellular location: Membrane; Single-pass type I membrane protein Tissue specificity: Central nervous system, skeletal muscle and aorta tissues. Miscellaneous: Binds gabapentin, an antiepileptic drug. Also known as: Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-gated calcium channel subunit alpha-2/delta-1, CACNL2A, CCHL2A, MHS3.

Specificity: Appears to be specific for CACNA2D1.

Application Details

Application Notes: IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Williams, Feldman, McCue et al.: "Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype." in: Neuron, Vol. 8, Issue 1, pp. 71-84, 1992 (PubMed).

Jay, Sharp, Kahl et al.: "Structural characterization of the dihydropyridine-sensitive calcium channel alpha 2-subunit and the associated delta peptides." in: The Journal of biological chemistry, Vol. 266, Issue 5, pp. 3287-93, 1991 (PubMed).

Hamilton, Hawkes, Brush et al.: "Subunit composition of the purified dihydropyridine binding protein from skeletal muscle." in: Biochemistry, Vol. 28, Issue 19, pp. 7820-8, 1990 (PubMed).

Liu, Qian, Gritsenko et al.: "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." in: Journal of proteome research, Vol. 4, Issue 6, pp. 2070-80, 2005 (PubMed).