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Details for Product No. ABIN350150

Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1) (N-Term) antibody

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Antigen
Synonyms CCHLA2, Cacna2, DHSCCA, CACNA2, CCHL2A, CACNL2A, Ca(v)alpha2delta1, Cchl2a, CACNA2D1, DKFZp469K2211
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN350150
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the n-terminal region of human CACNA2D1 (CACNL2A) conjugated to an immunogenic carrier protein was used as the antigen. The peptide shares 90% identity with the corresponding sequences in mouse and rat.
Specificity Specific for MOR42-3.
Purity IgG
Alternative Name CACNA2D1 (CACNL2A)
Background Function: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling.
Subcellular location: Membrane, Single-pass type I membrane protein
Tissue specificity: Central nervous system, skeletal muscle and aorta tissues.
Miscellaneous: Binds gabapentin, an antiepileptic drug. Also known as: Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-gated calcium channel subunit alpha-2/delta-1, CACNL2A, CCHL2A, MHS3.
UniProt Q9WU88
Application Notes A concentration of 10-50 µg/mL is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
Williams, Feldman, McCue et al.: "Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype." in: Neuron, Vol. 8, Issue 1, pp. 71-84, 1992 (PubMed).

Jay, Sharp, Kahl et al.: "Structural characterization of the dihydropyridine-sensitive calcium channel alpha 2-subunit and the associated delta peptides." in: The Journal of biological chemistry, Vol. 266, Issue 5, pp. 3287-93, 1991 (PubMed).

Hamilton, Hawkes, Brush et al.: "Subunit composition of the purified dihydropyridine binding protein from skeletal muscle." in: Biochemistry, Vol. 28, Issue 19, pp. 7820-8, 1990 (PubMed).

Liu, Qian, Gritsenko et al.: "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." in: Journal of proteome research, Vol. 4, Issue 6, pp. 2070-80, 2005 (PubMed).

Alternatives for antigen "Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1)", type "Antibodies"
Hosts (40), (6), (2)
Reactivities (43), (31), (30), (20), (19), (18), (3), (1), (1)
Applications (33), (18), (18), (10), (9), (5), (2), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (4), (2), (1), (1)
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