CACNA2D1 antibody (Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1) (AA 100-150)

Details for Product anti-CACNA2D1 Antibody No. ABIN350150, Supplier: Log in to see
Antigen
  • CACNA2D1
  • DKFZp469K2211
  • CACNA2
  • CACNL2A
  • CCHL2A
  • Ca(v)alpha2delta1
  • Cacna2
  • Cchl2a
  • CCHLA2
  • DHSCCA
  • calcium channel, voltage-dependent, alpha 2/delta subunit 1
  • calcium channel, voltage-dependent, alpha2/delta subunit 1
  • CACNA2D1
  • cacna2d1
  • Cacna2d1
Epitope
AA 100-150
25
11
4
4
2
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
71
18
18
4
4
3
2
2
2
Host
Rabbit
57
16
1
Clonality
Polyclonal
Conjugate
This CACNA2D1 antibody is un-conjugated
5
5
5
3
3
3
Application
Immunohistochemistry (IHC), Western Blotting (WB)
59
38
13
11
5
2
2
1
1
1
Options
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Immunogen A synthetic peptide from aa region 100-150 of human CACNA2D1 conjugated to an immunogenic carrier protein was used as the antigen.
Isotype IgG
Specificity Specific for CACNA2D1.
Alternative Name CACNA2D1 (CACNA2D1 Antibody Abstract)
Background Function: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling.
Subcellular location: Membrane, Single-pass type I membrane protein
Tissue specificity: Central nervous system, skeletal muscle and aorta tissues.
Miscellaneous: Binds gabapentin, an antiepileptic drug. Also known as: Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-gated calcium channel subunit alpha-2/delta-1, CACNL2A, CCHL2A, MHS3.
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Liu, Qian, Gritsenko, Camp, Monroe, Moore, Smith: "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." in: Journal of proteome research, Vol. 4, Issue 6, pp. 2070-80, 2005 (PubMed).

Williams, Feldman, McCue, Brenner, Velicelebi, Ellis, Harpold: "Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype." in: Neuron, Vol. 8, Issue 1, pp. 71-84, 1992 (PubMed).

Jay, Sharp, Kahl, Vedvick, Harpold, Campbell: "Structural characterization of the dihydropyridine-sensitive calcium channel alpha 2-subunit and the associated delta peptides." in: The Journal of biological chemistry, Vol. 266, Issue 5, pp. 3287-93, 1991 (PubMed).

Hamilton, Hawkes, Brush, Cook, Chang, Smilowitz: "Subunit composition of the purified dihydropyridine binding protein from skeletal muscle." in: Biochemistry, Vol. 28, Issue 19, pp. 7820-8, 1990 (PubMed).