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Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 4 (CACNA2D4) (Internal Region) antibody

Details for Product No. ABIN350154, Supplier: Login to see
Antigen
  • cacna2d4
  • cacna2d3b
  • si:ch211-87p6.2
  • RCD4
  • 5730412N02Rik
  • BE686333
  • RGD1562038
Epitope
Internal Region
16
9
7
3
2
1
1
1
1
Reactivity
Human
34
8
7
1
1
1
1
Host
Rabbit
34
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
32
23
14
Supplier
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Immunogen A synthetic peptide from the internal region of human CACNA2D4 conjugated to an immunogenic carrier protein was used as the antigen. The antigen shares 95% identity with mouse sequence.
Specificity Specific for CACNA2D4.
Purification Whole serum
Alternative Name CACNA2D4 (CACNA2D4 Antibody Abstract)
Background Function: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Defects in CACNA2D4 are the cause of retinal cone dystrophy 4 (RCD4). RCD4 is characterized by minimal symptoms except for slowly progressive reduction in visual acuity.
Tissue specificity: Predominantly expressed in certain types of endocrine cells. Present in the Paneth cells of the small intestine. Also present in the erythroblasts in the fetal liver, in the cells of the zona reticularis of the adrenal gland and in the basophiles of the pituitary. Present at low level in some brain regions such as the cerebellum (at protein level).
Subcellular location: Membrane, Single-pass type I membrane protein
Miscellaneous: In contrast to CACNA2D1 and CACNA2D2, it does not bind gabapentin, an antiepileptic drug. Also known as: Voltage-dependent calcium channel subunit alpha-2/delta-4, Voltage-gated calcium channel subunit alpha-2/delta-4.
Research Area Neurology
Pathways
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Wycisk, Zeitz, Feil et al.: "Mutation in the auxiliary calcium-channel subunit CACNA2D4 causes autosomal recessive cone dystrophy." in: American journal of human genetics, Vol. 79, Issue 5, pp. 973-7, 2006 (PubMed).

Qin, Yagel, Momplaisir et al.: "Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit." in: Molecular pharmacology, Vol. 62, Issue 3, pp. 485-96, 2002 (PubMed).