Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 4 (CACNA2D4) (Internal Region) antibody

Details for Product No. ABIN350154
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Antigen
Synonyms RCD4, RGD1562038, BE686333, 5730412N02Rik, cacna2d4, cacna2d3b, si:ch211-87p6.2
Epitope
Internal Region
(10), (2), (1), (1), (1)
Reactivity
Human
(20), (11), (10)
Host
Rabbit
(19), (1)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(19), (10), (1), (1), (1)
Pubmed 2 references available
Catalog no. ABIN350154
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from the internal region of human CACNA2D4 conjugated to an immunogenic carrier protein was used as the antigen. The antigen shares 95% identity with mouse sequence.
Specificity Specific for ASIC4.
Purification whole serum
Alternative Name CACNA2D4
Background Function: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Defects in CACNA2D4 are the cause of retinal cone dystrophy 4 (RCD4). RCD4 is characterized by minimal symptoms except for slowly progressive reduction in visual acuity.
Tissue specificity: Predominantly expressed in certain types of endocrine cells. Present in the Paneth cells of the small intestine. Also present in the erythroblasts in the fetal liver, in the cells of the zona reticularis of the adrenal gland and in the basophiles of the pituitary. Present at low level in some brain regions such as the cerebellum (at protein level).
Subcellular location: Membrane, Single-pass type I membrane protein
Miscellaneous: In contrast to CACNA2D1 and CACNA2D2, it does not bind gabapentin, an antiepileptic drug. Also known as: Voltage-dependent calcium channel subunit alpha-2/delta-4, Voltage-gated calcium channel subunit alpha-2/delta-4.
UniProt Q96FT7
Research Area Neurology
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Qin, Yagel, Momplaisir et al.: "Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit." in: Molecular pharmacology, Vol. 62, Issue 3, pp. 485-96, 2002 (PubMed).

Wycisk, Zeitz, Feil et al.: "Mutation in the auxiliary calcium-channel subunit CACNA2D4 causes autosomal recessive cone dystrophy." in: American journal of human genetics, Vol. 79, Issue 5, pp. 973-7, 2006 (PubMed).

Hosts (19), (1)
Reactivities (20), (11), (10)
Applications (19), (10), (1), (1), (1)
Epitopes (10), (2), (1), (1), (1)
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