Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 4 (CACNA2D4) (Internal Region) antibody

Antigen: Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 4 (CACNA2D4)

Synonyms: RCD4, RGD1562038, BE686333, 5730412N02Rik, cacna2d4, cacna2d3b, si:ch211-87p6.2

Binding Site: Internal Region

Clonality: Polyclonal

Host: Rabbit

Reactivity: Please enquire

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350154

Additional Information

Alternative name: CACNA2D4

UniProt: Q7Z3S7

Immunogen: A synthetic peptide from the internal region of human CACNA2D4 conjugated to an immunogenic carrier protein was used as the immunogen. The antigen shares 95% identity with mouse sequence.

Format: Lyophilized

Description: FUNCTION: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Defects in CACNA2D4 are the cause of retinal cone dystrophy 4 (RCD4). RCD4 is characterized by minimal symptoms except for slowly progressive reduction in visual acuity. Tissue specificity: Predominantly expressed in certain types of endocrine cells. Present in the Paneth cells of the small intestine. Also present in the erythroblasts in the fetal liver, in the cells of the zona reticularis of the adrenal gland and in the basophiles of the pituitary. Present at low level in some brain regions such as the cerebellum (at protein level). Subcellular location: Membrane; Single-pass type I membrane protein Miscellaneous: In contrast to CACNA2D1 and CACNA2D2, it does not bind gabapentin, an antiepileptic drug. Also known as: Voltage-dependent calcium channel subunit alpha-2/delta-4, Voltage-gated calcium channel subunit alpha-2/delta-4.

Specificity: Appears to be specific for CACNA2D4.

Application Details

Application Notes: IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Qin, Yagel, Momplaisir et al.: "Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit." in: Molecular pharmacology, Vol. 62, Issue 3, pp. 485-96, 2002 (PubMed).

Wycisk, Zeitz, Feil et al.: "Mutation in the auxiliary calcium-channel subunit CACNA2D4 causes autosomal recessive cone dystrophy." in: American journal of human genetics, Vol. 79, Issue 5, pp. 973-7, 2006 (PubMed).