Calcium Channel, Voltage-Dependent, beta 2 Subunit (CACNB2) (C-Term) antibody

Details for Product No. ABIN350157
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Antigen
Synonyms Cacnb2, CACNB2, CACNLB2, CAVB2, MYSB, CAB2, AW060387, Cavbeta2, Cchb2, Cacnlb2
Epitope
C-Term
(20), (17), (16), (15), (8), (8), (7), (3), (2), (1)
Reactivity
Human
(93), (53), (34), (21), (14), (9), (8), (2), (2)
Host
Rabbit
(77), (33), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(100), (22), (20), (17), (17), (10), (4), (2), (2), (1)
Pubmed 4 references available
Quantity 100 μL
Options
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Catalog No. ABIN350157
454.67 $
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Immunogen A synthetic peptide from the c-terminal region of human CACNB2 (CAB2, MYSB) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Specific for CACNB2.
Purification Whole serum
Alternative Name CACNB2
Background Function: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Defects in CACNB2 are the cause of Brugada syndrome type 4 (BRS4). BRS4 is a heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.
Subcellular location: Cell membrane › sarcolemma, Peripheral membrane protein, Cytoplasmic side
Tissue specificity: Expressed in all tissues. Also known as: Voltage-dependent L-type calcium channel subunit beta-2, CAB2, Calcium channel voltage-dependent subunit beta 2, Lambert-Eaton myasthenic syndrome antigen B, MYSB, CACNLB2.
Research Area Neurology
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user. Not tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Rosenfeld, Wong, Dalmau et al.: "Cloning and characterization of a Lambert-Eaton myasthenic syndrome antigen." in: Annals of neurology, Vol. 33, Issue 1, pp. 113-20, 1993 (PubMed).

Taviaux, Williams, Harpold et al.: "Assignment of human genes for beta 2 and beta 4 subunits of voltage-dependent Ca2+ channels to chromosomes 10p12 and 2q22-q23." in: Human genetics, Vol. 100, Issue 2, pp. 151-4, 1997 (PubMed).

Sjöblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers. ..." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).

Antzelevitch, Pollevick, Cordeiro et al.: "Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death." in: Circulation, Vol. 115, Issue 4, pp. 442-9, 2007 (PubMed).

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