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CACNB4 antibody (C-Term)

CACNB4 Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN350161
  • Target See all CACNB4 Antibodies
    CACNB4 (Calcium Channel, Voltage-Dependent, beta 4 Subunit (CACNB4))
    Binding Specificity
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 25
    • 16
    • 14
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 22
    • 4
    • 1
    Rabbit
    Clonality
    • 25
    • 2
    Polyclonal
    Conjugate
    • 16
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CACNB4 antibody is un-conjugated
    Application
    • 15
    • 9
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificity
    Specific for CACNB4.
    Cross-Reactivity
    Human, Mouse, Rat
    Cross-Reactivity (Details)
    Other species not yet tested.
    Purification
    IgG
    Immunogen
    A synthetic peptide from the c-terminal region of human CACNB4 (CACB4, Voltage dependent L-type calcium channel subunit beta-4) conjugated to an immunogenic carrier protein was used as the antigen. The antigen is homologous in many species including mouse and rat.
    Isotype
    IgG
    Top Product
    Discover our top product CACNB4 Primary Antibody
  • Application Notes
    IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.
    Handling Advice
    Avoid freeze and thaw cycles.
    Storage
    4 °C/-20 °C
    Storage Comment
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    Expiry Date
    12 months
  • Target
    CACNB4 (Calcium Channel, Voltage-Dependent, beta 4 Subunit (CACNB4))
    Alternative Name
    CACNB4 (CACNB4 Products)
    Synonyms
    CAB4 antibody, CACNLB4 antibody, EA5 antibody, EIG9 antibody, EJM antibody, EJM4 antibody, EJM6 antibody, 3110038O15Rik antibody, Cchb4 antibody, lethargic antibody, lh antibody, CACNB4 antibody, cacnb4.2 antibody, calcium voltage-gated channel auxiliary subunit beta 4 antibody, calcium channel, voltage-dependent, beta 4 subunit antibody, calcium channel, voltage-dependent, beta 4a subunit antibody, CACNB4 antibody, Cacnb4 antibody, cacnb4.1 antibody, cacnb4 antibody, cacnb4a antibody
    Background
    FUNCTION: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Defects in CACNB4 are associated with susceptibility to idiopathic generalized epilepsy (IGE). IGE is characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. Defects in CACNB4 are a cause of juvenile myoclonic epilepsy (EJM). EJM is a subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. Tissue specificity: Expressed predominantly in the cerebellum and kidney.,Beta Subunit,CACB4, Voltage-dependent L-type calcium channel subunit beta-4, Calcium channel voltage-dependent subunit beta 4
    UniProt
    O00305
    Pathways
    cAMP Metabolic Process, Skeletal Muscle Fiber Development
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