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Regulator of Calcineurin 1 (RCAN1) (Internal Region) antibody

Details for Product No. ABIN350174, Supplier: Log in to see
Antigen
  • RCAN1
  • dscr1
  • rcan1
  • wu:fr92c05
  • MGC53636
  • csp1
  • dsc1
  • rcn1
  • mcip1
  • adapt78
  • MGC69428
  • CDHF1
  • DG2/DG3
  • DSCR1
  • ADAPT78
  • CSP1
  • DSC1
  • MCIP1
  • RCN1
  • 2410048A02Rik
  • AA408855
  • AI429645
  • AL024459
  • AV028423
  • Adapt78
  • CALP1L
  • Dscr1
  • Mcip1
  • regulator of calcineurin 1
  • regulator of calcineurin 1b
  • Down syndrome critical region gene 1
  • desmocollin 1
  • DSCR1-like protein
  • RCAN1
  • rcan1b
  • dscr1
  • rcan1
  • DSC1
  • LOC443255
  • Rcan1
Epitope
Internal Region
40
25
19
19
16
11
9
7
5
5
4
3
2
2
2
2
1
1
1
1
1
1
Reactivity
Human, Rat (Rattus), Mouse (Murine)
155
81
46
6
6
3
3
3
3
3
2
2
2
1
Host
Rabbit
142
15
8
Clonality
Polyclonal
Conjugate
Un-conjugated
10
9
9
7
7
7
4
4
4
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
142
66
40
38
13
12
4
2
1
Options
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Immunogen A synthetic peptide from the internal region of human Calcipressin 1 (RCAN1, MCIP1) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for RCAN1.
Purification Whole serum
Alternative Name RCAN1 (RCAN1 Antibody Abstract)
Background Function: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
Tissue specificity: Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues. Also known as: Calcipressin-1, Calcipressin1, Regulator of calcineurin 1, Down syndrome critical region protein 1, Myocyte-enriched calcineurin-interacting protein 1, MCIP1, Adapt78, ADAPT78, CSP1, DSC1, DSCR1, RCAN1.
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Genescua, Aubareda, Fuentes, Estivill, De La Luna, Puerez-Riba: "Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life." in: The Biochemical journal, Vol. 374, Issue Pt 2, pp. 567-75, 2003 (PubMed).

Hattori, Fujiyama, Taylor, Watanabe, Yada, Park, Toyoda, Ishii, Totoki, Choi, Groner, Soeda, Ohki, Takagi, Sakaki, Taudien, Blechschmidt, Polley, Menzel, Delabar, Kumpf, Lehmann, Patterson, Reichwald et al.: "The DNA sequence of human chromosome 21. ..." in: Nature, Vol. 405, Issue 6784, pp. 311-9, 2000 (PubMed).

Fuentes, Pritchard, Estivill: "Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene." in: Genomics, Vol. 44, Issue 3, pp. 358-61, 1997 (PubMed).

Fuentes, Pritchard, Planas, Bosch, Ferrer, Estivill: "A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart." in: Human molecular genetics, Vol. 4, Issue 10, pp. 1935-44, 1996 (PubMed).