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Cathelicidin antibody (Cathelicidin Antimicrobial Peptide) (AA 40-80)

Details for Product anti-cAMP Antibody No. ABIN350181, Supplier: Log in to see
Antigen
  • CATH-2
  • CAP-18
  • CAP18
  • CRAMP
  • FALL-39
  • FALL39
  • LL37
  • Cnlp
  • Cramp
  • MCLP
  • CATHL7
  • CATH-B1
  • CATHB1
  • CATHL2
Epitope
AA 40-80
11
5
4
4
3
3
3
2
2
2
1
1
Reactivity
Human
67
28
20
6
1
1
Host
Sheep
85
9
5
1
1
Clonality
Polyclonal
Conjugate
This Cathelicidin antibody is un-conjugated
7
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
56
33
28
20
15
5
5
2
2
2
Supplier
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Immunogen A synthetic peptide from aa region 40-80 of human CAP-18 conjugated to blue carrier protein has been used as the antigen.
Specificity Specific for Cathelicidin antimicrobial peptide.
Purification Whole serum
Alternative Name CAP-18 (cAMP Antibody Abstract)
Background Cathelicidin antimicrobial protein is an antimicrobial protein found in specific granules of polymorphonuclear leukocytes.
Function: Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity.
Subcellular location: Secreted.
Tissue specificity: Expressed in bone marrow and testis and neutrophils. Also known as: CAMP, CAP18, FALL39, FALL-39, CAP-18, hCAP-18, CRAMP.
Pathways
Application Notes Use at a dilution of 1:100 to 1: 2000.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Bals, Lang, Weiner et al.: "Rhesus monkey (Macaca mulatta) mucosal antimicrobial peptides are close homologues of human molecules." in: Clinical and diagnostic laboratory immunology, Vol. 8, Issue 2, pp. 370-5, 2001 (PubMed).

Larrick, Lee, Ma et al.: "Structural, functional analysis and localization of the human CAP18 gene." in: FEBS letters, Vol. 398, Issue 1, pp. 74-80, 1997 (PubMed).

Gudmundsson, Agerberth, Odeberg et al.: "The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes." in: European journal of biochemistry / FEBS, Vol. 238, Issue 2, pp. 325-32, 1996 (PubMed).

Larrick, Hirata, Balint et al.: "Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein." in: Infection and immunity, Vol. 63, Issue 4, pp. 1291-7, 1995 (PubMed).

Cowland, Johnsen, Borregaard: "hCAP-18, a cathelin/pro-bactenecin-like protein of human neutrophil specific granules." in: FEBS letters, Vol. 368, Issue 1, pp. 173-6, 1995 (PubMed).

Agerberth, Gunne, Odeberg et al.: "FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 1, pp. 195-9, 1995 (PubMed).