Cathepsin G (CTSG) antibody

Antigen: Cathepsin G (CTSG)

Synonyms: CG, MGC23078, CTSG

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350192

Additional Information

Alternative name: Cathepsin G (CTSG protein)

Swiss-Prot: Q6IBJ6

Immunogen: A synthetic peptide from the human Cathepsin G (CTSG protein) conjugated to an immunogenic carrier protein has been used as the immunogen.

Format: Lyophilized

Description: The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. Transcript variants utilizing alternative polyadenylation signals exist for this gene. Also known as: CTSG protein, Cathepsin G, MGC23078.

Specificity: Appears to be specific for Cathepsin G.

Application Details

Application Notes: IHC, WB. Use at a dilution of 1:50 to 1: 500. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Sipahi, Pocan, Akar: "Effect of various genetic polymorphisms on the incidence and outcome of severe sepsis." in: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, Vol. 12, Issue 1, pp. 47-54, 2006 (PubMed).

Miyata, Tani, Sato et al.: "Cathepsin G: the significance in rheumatoid arthritis as a monocyte chemoattractant." in: Rheumatology international, Vol. 27, Issue 4, pp. 375-82, 2007 (PubMed).

Jahanyar, Youker, Loebe et al.: "Mast cell-derived cathepsin g: a possible role in the adverse remodeling of the failing human heart." in: The Journal of surgical research, Vol. 140, Issue 2, pp. 199-203, 2007 (PubMed).

Wysocka, Legowska, Bulak et al.: "New chromogenic substrates of human neutrophil cathepsin G containing non-natural aromatic amino acid residues in position P(1) selected by combinatorial chemistry methods." in: Molecular diversity, Vol. 11, Issue 2, pp. 93-9, 2007 (PubMed).

Gale, Rozenshteyn: "Cathepsin G, a leukocyte protease, activates coagulation factor VIII." in: Thrombosis and haemostasis, Vol. 99, Issue 1, pp. 44-51, 2008 (PubMed).