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Details for Product No. ABIN350194

Insulin-Like Growth Factor 2 Receptor (IGF2R) (Internal Region) antibody

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Antigen
Synonyms MPR1, MPRI, CD222, CIMPR, M6P-R, CI-MPR, M6P/IGF2R, Mpr300, AI661837, mpri, cd222, cimpr, m6p-r
Epitope
»Alternatives Internal Region
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus), Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350194
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the internal region of mouse Cation independent mannose 6 phosphate receptor (Insulin-like growth factor 2 receptor) conjugated to an immunogenic carrier protein was used as the immunogen. The peptide is homologous in rat and shares 95% identity with human's.
Specificity Appears to be specific for MPRI.
Purity whole serum
Alternative Name Cation independent mannose 6 phosphate receptor
Background Function: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2.
Subunit: Binds GGA1, GGA2 and GGA3.
Subcellular location: Lysosome membrane, Single-pass type I membrane protein. Also known as: CI Man-6-P receptor, CI-MPR, M6PR, Insulin-like growth factor 2 receptor, Insulin-like growth factor II receptor, IGF-II receptor, M6P/IGF2 receptor, M6P/IGF2R, 300 kDa mannose 6-phosphate receptor, MPR 300, CD222 antigen, IGF2R, MPRI.
UniProt Q07113
Application Notes IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
MacDonald, Pfeffer, Coussens et al.: "A single receptor binds both insulin-like growth factor II and mannose-6-phosphate." in: Science (New York, N.Y.), Vol. 239, Issue 4844, pp. 1134-7, 1988 (PubMed).

Szebenyi, Rotwein: "The mouse insulin-like growth factor II/cation-independent mannose 6-phosphate (IGF-II/MPR) receptor gene: molecular cloning and genomic organization." in: Genomics, Vol. 19, Issue 1, pp. 120-9, 1994 (PubMed).

Stoeger, Kubicka, Liu et al.: "Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal." in: Cell, Vol. 73, Issue 1, pp. 61-71, 1993 (PubMed).

Cantin, Yi, Lu et al.: "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." in: Journal of proteome research, Vol. 7, Issue 3, pp. 1346-51, 2008 (PubMed).

Dephoure, Zhou, Villén et al.: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).

Alternatives for antigen "Insulin-Like Growth Factor 2 Receptor (IGF2R)", type "Antibodies"
Hosts (46), (43), (1)
Reactivities (84), (36), (22), (17), (12), (12), (12), (12), (2), (1)
Applications (45), (37), (29), (20), (16), (10), (10), (7), (4), (3), (1)
Conjugates (9), (7), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (8), (4), (1), (1), (1)
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