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Details for Product No. ABIN350194

Insulin-Like Growth Factor 2 Receptor (IGF2R) (Internal Region) antibody

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Antigen
Synonyms MPR1, MPRI, CD222, CIMPR, M6P-R, CI-MPR, M6P/IGF2R, Mpr300, AI661837, mpri, cd222, cimpr, m6p-r
Epitope
»Alternatives Internal Region
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350194
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the internal region of human Cation independent mannose 6 phosphate receptor (Insulin-like growth factor 2 receptor) conjugated to an immunogenic carrier protein was used as the antigen.
Isotype IgG
Specificity Specific for CACNG7.
Purity whole serum
Alternative Name Cation independent mannose 6 phosphate receptor
Background Function: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2.
Subunit: Binds GGA1, GGA2 and GGA3.
Subcellular location: Lysosome membrane, Single-pass type I membrane protein. Also known as: CI Man-6-P receptor, CI-MPR, M6PR, Insulin-like growth factor 2 receptor, Insulin-like growth factor II receptor, IGF-II receptor, M6P/IGF2 receptor, M6P/IGF2R, 300 kDa mannose 6-phosphate receptor, MPR 300, CD222 antigen, IGF2R, MPRI.
UniProt P62957
Research Area Signaling
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
MacDonald, Pfeffer, Coussens et al.: "A single receptor binds both insulin-like growth factor II and mannose-6-phosphate." in: Science (New York, N.Y.), Vol. 239, Issue 4844, pp. 1134-7, 1988 (PubMed).

Szebenyi, Rotwein: "The mouse insulin-like growth factor II/cation-independent mannose 6-phosphate (IGF-II/MPR) receptor gene: molecular cloning and genomic organization." in: Genomics, Vol. 19, Issue 1, pp. 120-9, 1994 (PubMed).

Stoeger, Kubicka, Liu et al.: "Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal." in: Cell, Vol. 73, Issue 1, pp. 61-71, 1993 (PubMed).

Cantin, Yi, Lu et al.: "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." in: Journal of proteome research, Vol. 7, Issue 3, pp. 1346-51, 2008 (PubMed).

Dephoure, Zhou, Villén et al.: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).

Alternatives for antigen "Insulin-Like Growth Factor 2 Receptor (IGF2R)", type "Antibodies"
Hosts (46), (42), (1), (1)
Reactivities (85), (36), (22), (17), (12), (12), (12), (12), (2), (1)
Applications (45), (37), (29), (20), (16), (10), (10), (7), (4), (3), (1)
Conjugates (9), (7), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (8), (4), (1), (1), (1)
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