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Caveolin 1, Caveolae Protein (CAV1) (1st Cytoplasmic Domain) antibody
1st Cytoplasmic Domain
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
|5 references available|
|Quantity||150 µl (Variants)|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Alternative name||Caveolin-1 (CAV1, CAV)|
|Immunogen||A synthetic peptide from the 1t cytoplasmic domain of human Caveolin-1 (CAV1, CAV) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in many other species including rat, mouse.|
|Description||FUNCTION: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein. Note: Potential hairpin-like structure in the membrane. Membrane protein of protein of caveolae. TISSUE SPECIFICITY: In muscle and lung, less so in liver, brain and kidney. Also known as: CAV1, CAV.|
|Specificity||Appears to be specific for Caveolin-1.|
|Application Notes||IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
Eberle, Serrano, Fuellekrug et al.: "Identification and characterization of a novel human plant pathogenesis-related protein that localizes to lipid-enriched microdomains in the Golgi complex." in: Journal of cell science, Vol. 115, Issue Pt 4, pp. 827-38, 2002 (PubMed).
Aboulaich, Vainonen, Strålfors et al.: "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes." in: The Biochemical journal, Vol. 383, Issue Pt 2, pp. 237-48, 2004 (PubMed).
Schilling, Opitz, Wiesenthal et al.: "Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN." in: Molecular biology of the cell, Vol. 17, Issue 9, pp. 3870-80, 2006 (PubMed).
Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).
Dephoure, Zhou, Villén et al.: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).
|Hosts||Rabbit (2), Sheep (1)|
|Applications||Immunohistochemistry (IHC) (3), Western Blotting (WB) (3)|
|Epitopes||1st Cytoplasmic Domain (3)|