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Caveolin-1 antibody (Caveolin 1, Caveolae Protein, 22kDa) (1st Cytoplasmic Domain)

Details for Product anti-CAV1 Antibody No. ABIN350198, Supplier: Log in to see
Antigen
  • bscl3
  • BSCL3
  • Cav
  • cav
  • cav-1
  • Cav-1
  • cav1
  • CAV1
  • cav1a
  • cav1b
  • Caveolin-1
  • caveolin-1
  • caveolin 1
  • CGL3
  • cgl3
  • fc07c04
  • MSTP085
  • mstp085
  • PPH3
  • vip21
  • VIP21
  • wu:fc07c04
Epitope
1st Cytoplasmic Domain
37
27
20
11
9
8
7
5
5
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Mouse (Murine), Rat (Rattus), Human
227
107
101
24
17
9
9
8
8
6
3
3
3
3
3
2
1
1
1
1
1
1
1
1
1
Host
Sheep
182
35
32
2
Clonality
Polyclonal
Conjugate
This Caveolin-1 antibody is un-conjugated
6
4
3
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
185
65
53
49
48
29
19
9
5
5
2
2
2
1
Supplier
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Immunogen A synthetic peptide from the 1t cytoplasmic domain of human Caveolin-1 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in many other species including rat, mouse.
Isotype IgG
Specificity Specific for Caveolin-1.
Alternative Name CAV1 (CAV1 Antibody Abstract)
Background Function: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
Subcellular location: Golgi apparatus membrane, Single-pass membrane protein. Cell membrane, Single-pass membrane protein. Note: Potential hairpin-like structure in the membrane. Membrane protein of protein of caveolae.
Tissue specificity: In muscle and lung, less so in liver, brain and kidney. Also known as: CAV1, CAV.
Application Notes Use at a concentration of 10-50 µg/ml.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Dephoure, Zhou, Villén, Beausoleil, Bakalarski, Elledge, Gygi: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008

Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006

Schilling, Opitz, Wiesenthal, Oess, Tikkanen, Mueller-Esterl, Icking: "Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN." in: Molecular biology of the cell, Vol. 17, Issue 9, pp. 3870-80, 2006

Aboulaich, Vainonen, Strålfors, Vener: "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes." in: The Biochemical journal, Vol. 383, Issue Pt 2, pp. 237-48, 2004

Eberle, Serrano, Füllekrug, Schlosser, Lehmann, Lottspeich, Kaloyanova, Wieland, Helms: "Identification and characterization of a novel human plant pathogenesis-related protein that localizes to lipid-enriched microdomains in the Golgi complex." in: Journal of cell science, Vol. 115, Issue Pt 4, pp. 827-38, 2002