CD36 Molecule (thrombospondin Receptor) (CD36) (extracellular domain) antibody

Antigen: CD36 Molecule (thrombospondin Receptor) (CD36)

Synonyms: FAT, GP4, GP3B, GPIV, CHDS7, PASIV, SCARB3

Epitope: extracellular domain

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350202

Additional Information

Alternative name: CD36 (Fatty acid translocase) (extracellular domain)

Swiss-Prot: Q08857

Immunogen: A synthetic peptide from extracellular domain of mouse CD36 (Fatty acid translocase) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen shares 95% identity with rat sequence.

Format: Lyophilized

Description: FUNCTION: Seems to have numerous potential physiological functions. Recent compelling evidence from rodent and human studies raise the possibility for an additional sixth taste modality devoted to the perception of lipids. Recent studies strongly suggest that lingual CD36, being implicated in the perception of dietary fat, may act as a gustatory lipid sensor (1). Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Defects in CD36 are the cause of platelet glycoprotein IV deficiency; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Also known as: Platelet glycoprotein 4, Platelet glycoprotein IV,GPIV, Glycoprotein IIIb, GPIIIB, Leukocyte differentiation antigen CD36, PAS IV, PAS-4, Platelet collagen receptor, Fatty acid translocase, FAT, Thrombospondin receptor, CD36, GP3B, GP4.

Specificity: Appears to be specific for CD36.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Endemann, Stanton, Madden et al.: "CD36 is a receptor for oxidized low density lipoprotein." in: The Journal of biological chemistry, Vol. 268, Issue 16, pp. 11811-6, 1993 (PubMed).

Khan, Besnard: "Oro-sensory perception of dietary lipids: New insights into the fat taste transduction." in: Biochimica et biophysica acta, 2009 (PubMed).