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c-FOS antibody (C-Fos) (AA 300-380)

Details for Product anti-C-Fos Antibody No. ABIN350204, Supplier: Log in to see
Antigen
  • AP-1
  • C-FOS
  • p55
  • c-fos
  • D12Rfj1
  • cFos
  • cFOS
  • fos
Epitope
AA 300-380
40
23
22
20
19
18
16
13
11
9
6
6
6
6
5
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Rat (Rattus), Mouse (Murine)
325
159
157
15
15
12
3
2
2
1
Host
Rabbit
253
58
12
11
1
Clonality
Polyclonal
Conjugate
This c-FOS antibody is un-conjugated
7
7
6
6
3
3
3
3
3
3
3
3
3
3
3
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
247
128
95
38
34
22
18
13
13
9
8
6
2
1
1
1
Supplier
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Immunogen A synthetic peptide from aa region 300-380 of human cFos protein conjugated to an immunogenic carrier protein has been used as the antigen. The peptide is homologous in many other species including rat and mouse.
Specificity Specific for cFOS.
Purification Whole serum
Alternative Name c Fos
Background Function: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.
Subunit: Heterodimer. Interacts with DSIPI, this interaction inhibits the binding of active AP1 to its target DNA. Interacts with MAFB
Subcellular location: Nucleus. Also known as: Proto-oncogene protein cFOS, c-Fos.
Application Notes Use at a dilution of 1 : 300 to 1 : 2000.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Supplier Images
 image for anti-c-FOS antibody (C-Fos) (AA 300-380) (ABIN350204) IF on rat trigeminal using Mouse monoclonal antibody to rat p75NTR (ABIN350707) at a ...
 image for anti-c-FOS antibody (C-Fos) (AA 300-380) (ABIN350204) IF on rat trigeminal using Mouse monoclonal antibody to rat p75NTR (ABIN350707) at a ...
 image for anti-c-FOS antibody (C-Fos) (AA 300-380) (ABIN350204) IF on rat trigeminal using Rabbit antibody to cFos (c-fos): whole serum (ABIN350204) ...
Background publications Vasilescu, Zweitzig, Denis et al.: "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells." in: Journal of proteome research, Vol. 6, Issue 1, pp. 298-305, 2007 (PubMed).

Heilig, Eckenberg, Petit et al.: "The DNA sequence and analysis of human chromosome 14. ..." in: Nature, Vol. 421, Issue 6923, pp. 601-7, 2003 (PubMed).

Glover, Harrison: "Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA." in: Nature, Vol. 373, Issue 6511, pp. 257-61, 1995 (PubMed).

van Straaten, Müller, Curran et al.: "Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 80, Issue 11, pp. 3183-7, 1983 (PubMed).

Hai, Liu, Coukos et al.: "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers." in: Genes & development, Vol. 3, Issue 12B, pp. 2083-90, 1990 (PubMed).

Nakabeppu, Nathans: "The basic region of Fos mediates specific DNA binding." in: The EMBO journal, Vol. 8, Issue 12, pp. 3833-41, 1990 (PubMed).

Roux, Verrier, Klein et al.: "Retrovirus-mediated gene transfer of a human c-fos cDNA into mouse bone marrow stromal cells." in: Oncogene, Vol. 6, Issue 11, pp. 2155-60, 1991 (PubMed).