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Details for Product No. ABIN350207

C-Fos (AA 200-270) antibody

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Antigen
Synonyms D12Rfj1, c-fos, cFos, C-FOS
Epitope
»Alternatives AA 200-270
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 7 references available
Catalog no. ABIN350207
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from AA 200-270 of rat c Fos protein conjugated to an immunogenic carrier protein has been used as the antigen.
Specificity Specific for TAS2R45 ( and also TAS2R43, TAS2R44 and TAS2R47. See the Immunogen)
Purification Affinity purified
Purity whole serum
Alternative Name cFos (c-fos)
Background Function: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.
Subunit: Heterodimer. Interacts with DSIPI, this interaction inhibits the binding of active AP1 to its target DNA. Interacts with MAFB
Subcellular location: Nucleus. INDUCTION: C-fos expression increases upon a variety of stimuli, including growth factors, cytokines, neurotransmitters, polypeptide hormones, stress and cell injury. SIMILARITY: Belongs to the bZIP family. Fos subfamily SIMILARITY: Contains 1 bZIP domain Also known as: Proto-oncogene protein cFOS, c-Fos.
UniProt P59539
Application Notes Use at a dilution of 1 : 300 to 1 : 2000.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
Roux, Verrier, Klein et al.: "Retrovirus-mediated gene transfer of a human c-fos cDNA into mouse bone marrow stromal cells." in: Oncogene, Vol. 6, Issue 11, pp. 2155-60, 1991 (PubMed).

Nakabeppu, Nathans: "The basic region of Fos mediates specific DNA binding." in: The EMBO journal, Vol. 8, Issue 12, pp. 3833-41, 1990 (PubMed).

Hai, Liu, Coukos et al.: "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers." in: Genes & development, Vol. 3, Issue 12B, pp. 2083-90, 1990 (PubMed).

van Straaten, Mueller, Curran et al.: "Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 80, Issue 11, pp. 3183-7, 1983 (PubMed).

Glover, Harrison: "Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA." in: Nature, Vol. 373, Issue 6511, pp. 257-61, 1995 (PubMed).

Heilig, Eckenberg, Petit et al.: "The DNA sequence and analysis of human chromosome 14." in: Nature, Vol. 421, Issue 6923, pp. 601-7, 2003 (PubMed).

Vasilescu, Zweitzig, Denis et al.: "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells." in: Journal of proteome research, Vol. 6, Issue 1, pp. 298-305, 2007 (PubMed).

Alternatives for antigen "C-Fos", type "Antibodies"
Hosts (240), (39), (16), (3), (1)
Reactivities (267), (170), (160), (54), (43), (31), (25), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applications (202), (129), (70), (59), (56), (15), (14), (11), (8), (7), (7), (3), (3), (2), (1), (1), (1), (1)
Conjugates (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (1), (1)
Epitopes (29), (20), (18), (18), (17), (16), (16), (15), (6), (5), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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