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Details for Product No. ABIN350208

Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) (C-Term) antibody

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Synonyms CF, MRP7, ABC35, ABCC7, CFTR/MRP, TNR-CFTR, dJ760C5.1, AW495489, Abcc7, RGD1561193, CFTR
»Alternatives C-Term
»Alternatives Human
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN350208
Quantity 100 µL
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the c-terminal region of human CFTR conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Appears to be specific for CFTR.
Purification Affinity purified using solid phase Rabbit IgG
Purity whole serum
Alternative Name CFTR
Background Function: Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Defects in CFTR are the cause of congenital bilateral absence of the vas deferens (CBAVD). CBAVD is an important cause of sterility in men and could represent an incomplete form of cystic fibrosis, as the majority of men suffering from cystic fibrosis lack the vas deferens.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Found on the surface of the epithelial cells that line the lungs and other organs. Also known as: Cystic fibrosistransmembrane conductance regulator, Channel conductance-controlling ATPase, cAMP-dependent chloride channel, ATP-binding cassette transporter sub-family C member 7.
UniProt P13569
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Riordan, Rommens, Kerem et al.: "Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA." in: Science (New York, N.Y.), Vol. 245, Issue 4922, pp. 1066-73, 1989 (PubMed).

Chang, Hou, Jensen et al.: "Mapping of cystic fibrosis transmembrane conductance regulator membrane topology by glycosylation site insertion." in: The Journal of biological chemistry, Vol. 269, Issue 28, pp. 18572-5, 1994 (PubMed).

Gouya, Pascaud, Munck et al.: "Novel mutation (A141D) in exon 4 of the CFTR gene identified in an Algerian patient." in: Human mutation, Vol. 10, Issue 1, pp. 86-7, 1997 (PubMed).

Cheng, Moyer, Milewski et al.: "A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression." in: The Journal of biological chemistry, Vol. 277, Issue 5, pp. 3520-9, 2002 (PubMed).

Alternatives for antigen "Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR)", type "Antibodies"
Hosts (46), (33), (3)
Reactivities (79), (29), (27), (14), (14), (12), (12), (1), (1), (1)
Applications (53), (31), (28), (27), (26), (13), (12), (10), (2), (2), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (5), (5), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)