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CFTR antibody (Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7)) (AA 1150-1200)

Details for Product anti-CFTR Antibody No. ABIN350208, Supplier: Log in to see
Antigen
  • ABC35
  • abc35
  • abcc7
  • ABCC7
  • Abcc7
  • AW495489
  • CF
  • CFTR
  • cftr/mrp
  • CFTR/MRP
  • dJ760C5.1
  • mrp7
  • MRP7
  • RGD1561193
  • TNR-CFTR
  • tnr-cftr
  • xcftr
Epitope
AA 1150-1200
12
6
6
5
4
4
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
86
30
21
3
2
2
2
2
1
1
Host
Rabbit
46
29
12
Clonality
Polyclonal
Conjugate
This CFTR antibody is un-conjugated
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
60
30
28
28
26
24
8
7
3
2
2
2
2
1
1
Supplier
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Immunogen A synthetic peptide from aa region 1150-1200 of human ABCC7 conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for CFTR.
Purification Whole serum
Alternative Name ABCC7 (CFTR Antibody Abstract)
Background Function: Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Defects in CFTR are the cause of congenital bilateral absence of the vas deferens (CBAVD). CBAVD is an important cause of sterility in men and could represent an incomplete form of cystic fibrosis, as the majority of men suffering from cystic fibrosis lack the vas deferens.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Found on the surface of the epithelial cells that line the lungs and other organs. Also known as: Cystic fibrosistransmembrane conductance regulator, Channel conductance-controlling ATPase, cAMP-dependent chloride channel, ATP-binding cassette transporter sub-family C member 7.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Cheng, Moyer, Milewski, Loffing, Ikeda, Mickle, Cutting, Li, Stanton, Guggino: "A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression." in: The Journal of biological chemistry, Vol. 277, Issue 5, pp. 3520-9, 2002 (PubMed).

Gouya, Pascaud, Munck, Elion, Denamur: "Novel mutation (A141D) in exon 4 of the CFTR gene identified in an Algerian patient." in: Human mutation, Vol. 10, Issue 1, pp. 86-7, 1997 (PubMed).

Chang, Hou, Jensen, Riordan: "Mapping of cystic fibrosis transmembrane conductance regulator membrane topology by glycosylation site insertion." in: The Journal of biological chemistry, Vol. 269, Issue 28, pp. 18572-5, 1994 (PubMed).

Riordan, Rommens, Kerem, Alon, Rozmahel, Grzelczak, Zielenski, Lok, Plavsic, Chou: "Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA." in: Science (New York, N.Y.), Vol. 245, Issue 4922, pp. 1066-73, 1989 (PubMed).