Chloride Channel 1, Skeletal Muscle (CLCN1) (N-Term) antibody

Details for Product No. ABIN350218
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Synonyms CLC1, Clc-1, Clc1, SMCC1, adr, mto, myotonia, nmf355, SMCC, CLCN1, si:dkey-14o18.5
Rat (Rattus)
(6), (6), (2)
(8), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(9), (4), (1), (1)
Pubmed 5 references available
Catalog no. ABIN350218
Quantity 100 µL
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Immunogen A synthetic peptide from the n-terminal region of human Chloride channel protein 1 (CLCN1) conjugated to an immunogenic carrier protein was used as the antigen.
Isotype IgG1
Specificity Specific for rat p75NTR.
Purification whole serum
Alternative Name Chloride channel protein 1 (CLCN1)
Background Function: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Predominantly expressed in skeletal muscles. Also known as: Skeletal muscle Chloride channel protein 1, ClC-1, CLCN1, CLC1.
UniProt P07174
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Koch, Steinmeyer, Lorenz et al.: "The skeletal muscle chloride channel in dominant and recessive human myotonia." in: Science (New York, N.Y.), Vol. 257, Issue 5071, pp. 797-800, 1992 (PubMed).

Lehmann-Horn, Mailaender, Heine et al.: "Myotonia levior is a chloride channel disorder." in: Human molecular genetics, Vol. 4, Issue 8, pp. 1397-402, 1995 (PubMed).

Lorenz, Meyer-Kleine, Steinmeyer et al.: "Genomic organization of the human muscle chloride channel CIC-1 and analysis of novel mutations leading to Becker-type myotonia." in: Human molecular genetics, Vol. 3, Issue 6, pp. 941-6, 1994 (PubMed).

Steinmeyer, Lorenz, Pusch et al.: "Multimeric structure of ClC-1 chloride channel revealed by mutations in dominant myotonia congenita (Thomsen)." in: The EMBO journal, Vol. 13, Issue 4, pp. 737-43, 1994 (PubMed).

Sjöblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).

Hosts (8), (1)
Reactivities (6), (6), (2)
Applications (9), (4), (1), (1)
Epitopes (5)
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