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Details for Product No. ABIN350218

Chloride Channel 1, Skeletal Muscle (CLCN1) (N-Term) antibody

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Antigen
Synonyms CLC1, Clc-1, Clc1, SMCC1, adr, mto, myotonia, nmf355, SMCC, CLCN1, si:dkey-14o18.5
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350218
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the n-terminal region of human Chloride channel protein 1 (CLCN1) conjugated to an immunogenic carrier protein was used as the immunogen.
Specificity Appears to be specific for CLCN1.
Purity whole serum
Alternative Name Chloride channel protein 1 (CLCN1)
Background Function: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Predominantly expressed in skeletal muscles. Also known as: Skeletal muscle Chloride channel protein 1, ClC-1, CLCN1, CLC1.
UniProt P35523
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Koch, Steinmeyer, Lorenz et al.: "The skeletal muscle chloride channel in dominant and recessive human myotonia." in: Science (New York, N.Y.), Vol. 257, Issue 5071, pp. 797-800, 1992 (PubMed).

Lehmann-Horn, Mailaender, Heine et al.: "Myotonia levior is a chloride channel disorder." in: Human molecular genetics, Vol. 4, Issue 8, pp. 1397-402, 1995 (PubMed).

Lorenz, Meyer-Kleine, Steinmeyer et al.: "Genomic organization of the human muscle chloride channel CIC-1 and analysis of novel mutations leading to Becker-type myotonia." in: Human molecular genetics, Vol. 3, Issue 6, pp. 941-6, 1994 (PubMed).

Steinmeyer, Lorenz, Pusch et al.: "Multimeric structure of ClC-1 chloride channel revealed by mutations in dominant myotonia congenita (Thomsen)." in: The EMBO journal, Vol. 13, Issue 4, pp. 737-43, 1994 (PubMed).

Sjöblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).

Alternatives for antigen "Chloride Channel 1, Skeletal Muscle (CLCN1)", type "Antibodies"
Hosts (9)
Reactivities (6), (5), (2)
Applications (9), (4), (1), (1)
Epitopes (5)
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