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Chloride Channel 3 (CLCN3) (Cytoplasmic Domain) antibody

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Synonyms CLCN3, clc3, clc-3, fb78c02, wu:fb78c02, Clc3, CLC3, ClC-3
Cytoplasmic Domain
(35), (35), (18), (15), (13), (13), (10), (8), (2), (2), (1)
Human, Rat (Rattus), Mouse (Murine)
(61), (57), (35), (2), (1), (1), (1), (1), (1), (1)
(43), (40), (2)
(5), (5), (4), (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(71), (44), (36), (21), (17), (11), (3), (1), (1), (1)
Pubmed 4 references available
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Quantity 100 μL
Shipping to United States ( )
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the cytoplasmic domain of rat Chloride channel protein 3 (CLCN3) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for CLCN3.
Purification Whole serum
Alternative Name CLCN3 (CLCN3 Antibody Abstract)
Background Function: Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Expressed primarily in tissues derived from neuroectoderm. Within the brain, its expression is particularly evident in the hippocampus,olfactory cortex, andolfactory bulb. Highly expressed in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Also expressed in tracheal and alveolar epithelial cells, and intima and media of thePulmonary vessels. Expressed in bronchus and colon (at protein level). Also known as: ClC-3, CLCN3, CLC3.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Gentzsch, Cui, Mengos et al.: "The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins." in: The Journal of biological chemistry, Vol. 278, Issue 8, pp. 6440-9, 2003 (PubMed).

Huang, Liu, Di et al.: "Regulation of human CLC-3 channels by multifunctional Ca2+/calmodulin-dependent protein kinase." in: The Journal of biological chemistry, Vol. 276, Issue 23, pp. 20093-100, 2001 (PubMed).

Lamb, Clayton, Liu et al.: "Expression of CLCN voltage-gated chloride channel genes in human blood vessels." in: Journal of molecular and cellular cardiology, Vol. 31, Issue 3, pp. 657-66, 1999 (PubMed).

Borsani, Rugarli, Taglialatela et al.: "Characterization of a human and murine gene (CLCN3) sharing similarities to voltage-gated chloride channels and to a yeast integral membrane protein." in: Genomics, Vol. 27, Issue 1, pp. 131-41, 1995 (PubMed).

Catalog No. ABIN350219
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