Chloride Channel, Voltage-Sensitive 6 (CLCN6) (Cytoplasmic Domain) antibody

Antigen: Chloride Channel, Voltage-Sensitive 6 (CLCN6)

Binding Site: Cytoplasmic Domain

Clonality: Polyclonal

Host: Rabbit

Reactivity: Please enquire

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350220

Additional Information

Alternative name: Chloride channel protein 6 (CLCN6)

UniProt: P51797

Immunogen: A synthetic peptide from the cytoplasmic domain of human Chloride channel protein 6 (CLCN6) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter. Subcellular location: Membrane, Multi-pass membrane protein. Note: Detected in detergent-resistant lipid rafts. Tissue specificity: Testis, ovary, small intestine, brain and skeletal muscle. Low level expression in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Isoform C is only detected in kidney. Also known as: ClC-6, CLCN6, CLC6.

Specificity: Appears to be specific for CLCN6.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Nomura, Nagase, Miyajima et al.: "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 1, Issue 5, pp. 223-9, 1995 (PubMed).

Lamb, Clayton, Liu et al.: "Expression of CLCN voltage-gated chloride channel genes in human blood vessels." in: Journal of molecular and cellular cardiology, Vol. 31, Issue 3, pp. 657-66, 1999 (PubMed).

Kornak, Boesl, Kubisch: "Complete genomic structure of the CLCN6 and CLCN7 putative chloride channel genes(1)." in: Biochimica et biophysica acta, Vol. 1447, Issue 1, pp. 100-6, 1999 (PubMed).

Nakajima, Okazaki, Yamakawa et al.: "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 9, Issue 3, pp. 99-106, 2002 (PubMed).

Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).