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Chloride Channel, Voltage-Sensitive 6 (CLCN6) (Cytoplasmic Domain) antibody

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Antigen
  • AI850629
  • CLC-6
  • chloride channel 6
  • chloride channel, voltage-sensitive 6
  • CLCN6
  • Clcn6
Epitope
Cytoplasmic Domain
6
3
2
1
1
1
1
Reactivity
Human
19
10
10
5
4
2
2
2
1
1
1
Host
Rabbit
18
3
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
19
11
2
1
1
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Immunogen A synthetic peptide from the cytoplasmic domain of human Chloride channel protein 6 (CLCN6) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for CLCN6.
Purification Whole serum
Alternative Name CLCN6 (CLCN6 Antibody Abstract)
Background Function: Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter.
Subcellular location: Membrane, Multi-pass membrane protein. Note: Detected in detergent-resistant lipid rafts.
Tissue specificity: Testis, ovary, small intestine, brain and skeletal muscle. Low level expression in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Isoform C is only detected in kidney. Also known as: ClC-6, CLCN6, CLC6.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: "The DNA sequence and biological annotation of human chromosome 1. ..." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).

Nakajima, Okazaki, Yamakawa, Kikuno, Ohara, Nagase: "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 9, Issue 3, pp. 99-106, 2002 (PubMed).

Kornak, Boesl, Kubisch: "Complete genomic structure of the CLCN6 and CLCN7 putative chloride channel genes(1)." in: Biochimica et biophysica acta, Vol. 1447, Issue 1, pp. 100-6, 1999 (PubMed).

Lamb, Clayton, Liu, Smith, Barna, Schutte: "Expression of CLCN voltage-gated chloride channel genes in human blood vessels." in: Journal of molecular and cellular cardiology, Vol. 31, Issue 3, pp. 657-66, 1999 (PubMed).

Nomura, Nagase, Miyajima, Sazuka, Tanaka, Sato, Seki, Kawarabayasi, Ishikawa, Tabata: "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 1, Issue 5, pp. 223-9, 1995 (PubMed).