Chloride Channel 7 (CLCN7) (cytoplasmic domain) antibody

Antigen: Chloride Channel 7 (CLCN7)

Synonyms: CLC7, CLC-7, OPTA2, OPTB4, FLJ26686, FLJ39644, FLJ46423, ClC-7, AA409691, AW538136, D17Wsu51e, MGC80627, CLCN7, im:7155923, zgc:153490

Epitope: cytoplasmic domain

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350221

Additional Information

Alternative name: Chloride channel protein 7 (CLCN7) (cytoplasmic domain)

Swiss-Prot: P51798

Immunogen: A synthetic peptide from the cytoplasmic domain of human Chloride channel protein 7 (CLCN7) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: FUNCTION: Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen. Subcellular location: Lysosome membrane; Multi-pass membrane protein. Tissue specificity: Brain, testis, muscle and kidney. Also known as: ClC-7, CLCN7, CLC7.

Specificity: Appears to be specific for CLCN7.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Frattini, Pangrazio, Susani et al.: "Chloride channel ClCN7 mutations are responsible for severe recessive, dominant, and intermediate osteopetrosis." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 18, Issue 10, pp. 1740-7, 2003 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Martin, Han, Gordon et al.: "The sequence and analysis of duplication-rich human chromosome 16." in: Nature, Vol. 432, Issue 7020, pp. 988-94, 2004 (PubMed).

Lam, Tong, Wong et al.: "DNA-based diagnosis of malignant osteopetrosis by whole-genome scan using a single-nucleotide polymorphism microarray: standardization of molecular investigations of genetic diseases due to consanguinity." in: Journal of human genetics, Vol. 52, Issue 1, pp. 98-101, 2006 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).