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Chloride Channel, Voltage-Sensitive 7 (CLCN7) (AA 250-300) antibody

Details for Product No. ABIN350221, Supplier: Log in to see
Antigen
  • AA409691
  • AW538136
  • ClC-7
  • D17Wsu51e
  • CLC-7
  • CLC7
  • OPTA2
  • OPTB4
  • PPP1R63
Epitope
AA 250-300
22
16
13
4
3
2
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
46
16
12
Host
Rabbit
45
5
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Immunohistochemistry (IHC), Western Blotting (WB)
43
36
19
15
9
3
1
1
Supplier
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Immunogen A synthetic peptide from aa region 250-300 of human CLCN7 conjugated to blue carrier protein was used as the antigen. The antigen is homologous in rat and mouse.
Specificity Specific for CLCN7.
Purification Whole serum
Alternative Name CLCN7 (CLCN7 Antibody Abstract)
Background Function: Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen.
Subcellular location: Lysosome membrane, Multi-pass membrane protein.
Tissue specificity: Brain, testis, muscle and kidney. Also known as: ClC-7, CLCN7, CLC7.
Pathways
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Lam, Tong, Wong et al.: "DNA-based diagnosis of malignant osteopetrosis by whole-genome scan using a single-nucleotide polymorphism microarray: standardization of molecular investigations of genetic diseases due to consanguinity." in: Journal of human genetics, Vol. 52, Issue 1, pp. 98-101, 2006 (PubMed).

Martin, Han, Gordon et al.: "The sequence and analysis of duplication-rich human chromosome 16. ..." in: Nature, Vol. 432, Issue 7020, pp. 988-94, 2004 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Frattini, Pangrazio, Susani et al.: "Chloride channel ClCN7 mutations are responsible for severe recessive, dominant, and intermediate osteopetrosis." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 18, Issue 10, pp. 1740-7, 2003 (PubMed).