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Details for Product No. ABIN350223

Charged Multivesicular Body Protein 2A (CHMP2A) (N-Term) antibody

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Antigen
Synonyms BC2, BC-2, VPS2, CHMP2, VPS2A, 1500016L11Rik, RGD1305050, bc-2, bc2, chmp2, vps2, vps2a
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350223
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the n-terminal of human CHMP2A (Charged multivesicular body protein 2A) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and mouse.
Specificity Appears to be specific for CHMP2A.
Purity whole serum
Alternative Name CHMP2A (Charged multivesicular body protein 2A)
Background Function: Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery oftransmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-III complex is probably involved in the concentration of MVB cargo. In case of infection, the HIV-1 virus takes advantage of the ESCRT-III complex for budding and exocytic cargos of viral proteins.
Subcellular location: Late endosome membrane, Peripheral membrane protein, Cytoplasmic side.
Miscellaneous: Its overexpression strongly inhibits HIV-1 release. Also known as: Chromatin-modifying protein 2a, Vacuolar protein-sorting-associated protein 2-1, Vps2-1, hVps2-1, Putative breast adenocarcinoma marker BC-2, BC2, Charged multivesicular body protein 2a.
UniProt O43633
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Howard, Stauffer, Degnin et al.: "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins." in: Journal of cell science, Vol. 114, Issue Pt 13, pp. 2395-404, 2001 (PubMed).

Gevaert, Goethals, Martens et al.: "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides." in: Nature biotechnology, Vol. 21, Issue 5, pp. 566-9, 2003 (PubMed).

von Schwedler, Stuchell, Mueller et al.: "The protein network of HIV budding." in: Cell, Vol. 114, Issue 6, pp. 701-13, 2003 (PubMed).

Kemmer, Podowski, Arenillas et al.: "NovelFam3000--uncharacterized human protein domains conserved across model organisms." in: BMC genomics, Vol. 7, pp. 48, 2006 (PubMed).

Nousiainen, Silljé, Sauer et al.: "Phosphoproteome analysis of the human mitotic spindle." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 14, pp. 5391-6, 2006 (PubMed).

Alternatives for antigen "Charged Multivesicular Body Protein 2A (CHMP2A)", type "Antibodies"
Hosts (12), (1)
Reactivities (12), (3), (3)
Applications (10), (6), (4), (1), (1), (1)
Conjugates (1), (1), (1)
Epitopes (2), (2), (1)
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