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Cyclic Nucleotide Gated Channel alpha 2 (CNGA2) (AA 600-650) antibody

Details for Product No. ABIN350234, Supplier: Log in to see
Antigen
  • Cnca
  • CNCA
  • CNCA1
  • CNCG2
  • Cncg4
  • CNG2
  • CNGA2
  • HCN2
  • OCNC1
  • OCNCa
  • OCNCALPHA
  • OLFCH
  • si:dkey-28h18.1
  • wu:fj61d07
Epitope
AA 600-650
36
17
15
3
3
2
2
2
1
1
1
1
1
Reactivity
Rat (Rattus), Mouse (Murine), Human
75
32
31
Host
Rabbit
84
Clonality
Polyclonal
Conjugate
Un-conjugated
5
5
5
4
4
4
2
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
59
47
25
14
12
12
10
3
1
1
1
Supplier
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Immunogen A synthetic peptide from aa region 600-650 of rat CNGA2 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse and human.
Specificity Specific for CNGA2.
Purification Whole serum
Alternative Name CNGA2 (CNGA2 Antibody Abstract)
Background Function: Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. Theolfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization ofolfactory sensory neurons. Subunit structure: Heterooligomer of OCNC1 and OCNC2 subunits.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity:olfactory neurons. Also known as: Cyclic nucleotide-gatedolfactory channel, Cyclic nucleotide-gated cation channel 2, CNG channel alpha-2, CNG-2, CNG2, CNCA, CNCA1, CNCG2.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Sjöblom, Jones, Wood, Parsons, Lin, Barber, Mandelker, Leary, Ptak, Silliman, Szabo, Buckhaults, Farrell, Meeh, Markowitz, Willis, Dawson, Willson, Gazdar, Hartigan, Wu, Liu, Parmigiani, Park et al.: "The consensus coding sequences of human breast and colorectal cancers. ..." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).

Strijbos, Pratt, Khan, Charles, Garthwaite: "Molecular characterization and in situ localization of a full-length cyclic nucleotide-gated channel in rat brain." in: The European journal of neuroscience, Vol. 11, Issue 12, pp. 4463-7, 2000 (PubMed).

Ruiz, London, Nadal-Ginard: "Cloning and characterization of an olfactory cyclic nucleotide-gated channel expressed in mouse heart." in: Journal of molecular and cellular cardiology, Vol. 28, Issue 7, pp. 1453-61, 1996 (PubMed).

Distler, Biel, Flockerzi, Hofmann: "Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells." in: Neuropharmacology, Vol. 33, Issue 11, pp. 1275-82, 1995 (PubMed).

Dhallan, Yau, Schrader, Reed: "Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons." in: Nature, Vol. 347, Issue 6289, pp. 184-7, 1990 (PubMed).