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Details for Product No. ABIN350236

Cofilin 1 (Non-Muscle) (CFL1) (Internal Region) antibody

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Antigen
Synonyms
CFL, CFL1, AA959946, Cof, cfl1, xac1, xac2, cfl, cb86, sb:cb86, zgc:56501, wu:fb18a04, wu:fk77b03, 12/8, ADF, ADF/cofilin, Adf, CG4254, Cadf, D-cof, D61, Dmel\\CG4254, T8, Tsr, cofilin, cofilin/ADF, c ... show more
Epitope
»Alternatives Internal Region
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350236
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the internal part of human Cofilin-1 (Cofilin, non-muscle isoform) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat, mouse.
Specificity Specific for TPPC3.
Purity IgG
Alternative Name Cofilin-1 (Cofilin, non-muscle isoform)
Background Function: Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.
Subcellular location: Nucleus matrix. Cytoplasm, cytoskeleton. Note: Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.
Tissue specificity: Widely distributed in various tissues. Also known as: Cofilin, non-muscle isoform.
UniProt Q5U1Z2
Research Area Signaling
Application Notes A concentration of 10-50 µg/mL is recommended.
The optimal concentration should be determined by the end user.
Not tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
Ogawa, Tashima, Yumoto et al.: "Coding sequence of human placenta cofilin cDNA." in: Nucleic acids research, Vol. 18, Issue 23, pp. 7169, 1991 (PubMed).

Davidson, Haslam: "Dephosphorylation of cofilin in stimulated platelets: roles for a GTP-binding protein and Ca2+." in: The Biochemical journal, Vol. 301 ( Pt 1), pp. 41-7, 1994 (PubMed).

Nakano, Kanai-Azuma, Kanai et al.: "Cofilin phosphorylation and actin polymerization by NRK/NESK, a member of the germinal center kinase family." in: Experimental cell research, Vol. 287, Issue 2, pp. 219-27, 2003 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Rikova, Guo, Zeng et al.: "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." in: Cell, Vol. 131, Issue 6, pp. 1190-203, 2007 (PubMed).

Alternatives for antigen "Cofilin 1 (Non-Muscle) (CFL1)", type "Antibodies"
Hosts (107), (25), (4)
Reactivities (133), (81), (70), (24), (24), (13), (13), (12)
Applications (93), (42), (42), (39), (24), (20), (7), (6), (3), (3), (3), (2), (2)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (22), (20), (13), (11), (6), (6), (4), (4), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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