Cofilin 1 (Non-Muscle) (CFL1) antibody

Details for Product No. ABIN350238
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Antigen
Synonyms
CFL, CFL1, AA959946, Cof, cfl1, xac1, xac2, cfl, cb86, sb:cb86, zgc:56501, wu:fb18a04, wu:fk77b03, 12/8, ADF, ADF/cofilin, Adf, CG4254, Cadf, D-cof, D61, Dmel\\CG4254, T8, Tsr, cofilin, cofilin/ADF, c ... show more
CFL, CFL1, AA959946, Cof, cfl1, xac1, xac2, cfl, cb86, sb:cb86, zgc:56501, wu:fb18a04, wu:fk77b03, 12/8, ADF, ADF/cofilin, Adf, CG4254, Cadf, D-cof, D61, Dmel\\CG4254, T8, Tsr, cofilin, cofilin/ADF, cofilin/actin depolymerizing factor homolog, l(2)03101, l(2)k03101, l(2)k05633, l(2)k13409, ntf show less
Reactivity
Human
(209), (143), (138), (60), (52), (36), (28), (25), (12), (4)
Host
Rabbit
(182), (31), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(143), (78), (50), (50), (48), (25), (12), (5), (4), (3), (2), (1)
Pubmed 5 references available
Catalog no. ABIN350238
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from the phospho Y140 & S156 of human Cofilin-1 (Cofilin, non-muscle isoform) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat, mouse and monkey.
Specificity Specific for CATSPER1.
Purification whole serum
Alternative Name Cofilin-1 (Cofilin, non-muscle isoform)
Background Function: Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.
Subcellular location: Nucleus matrix. Cytoplasm, cytoskeleton. Note: Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.
Tissue specificity: Widely distributed in various tissues. Also known as: Cofilin, non-muscle isoform.
UniProt Q8NEC5
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user. This antibody may also recognice the unphosphorylated form.
Not tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Ogawa, Tashima, Yumoto et al.: "Coding sequence of human placenta cofilin cDNA." in: Nucleic acids research, Vol. 18, Issue 23, pp. 7169, 1991 (PubMed).

Davidson, Haslam: "Dephosphorylation of cofilin in stimulated platelets: roles for a GTP-binding protein and Ca2+." in: The Biochemical journal, Vol. 301 ( Pt 1), pp. 41-7, 1994 (PubMed).

Nakano, Kanai-Azuma, Kanai et al.: "Cofilin phosphorylation and actin polymerization by NRK/NESK, a member of the germinal center kinase family." in: Experimental cell research, Vol. 287, Issue 2, pp. 219-27, 2003 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Rikova, Guo, Zeng et al.: "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." in: Cell, Vol. 131, Issue 6, pp. 1190-203, 2007 (PubMed).

Hosts (182), (31), (3)
Reactivities (209), (143), (138), (60), (52), (36), (28), (25), (12), (4)
Applications (143), (78), (50), (50), (48), (25), (12), (5), (4), (3), (2), (1)
Conjugates (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Epitopes (45), (21), (14), (12), (12), (8), (7), (4), (4), (4), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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