coiled-coil myosin-like BCL2-interacting protein (Beclin-1, BECN1, ATG6) (C-Term) antibody

Antigen: coiled-coil myosin-like BCL2-interacting protein (Beclin-1, BECN1, ATG6)

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Fruit Fly (Drosophila melanogaster)

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350241

Additional Information

UniProt: Q9VCE1

Immunogen: A synthetic peptide from the c-terminal part of drosophila coiled-coil myosin-like BCL2-interacting protein (Beclin-1, BECN1, ATG6) conjugated to an immunogenic carrier protein has been used as the immunogen.

Format: Lyophilized

Description: Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly.autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels ofautophagy have been described in some malignant tumors, and a role forautophagy in controlling the unregulated cell growth linked to cancer has been proposed. It may play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus. May play a role inautophagy. SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. TISSUE SPECIFICITY: Ubiquitous Also known as: Beclin-1, BECN1, ATG6, beclin1.

Specificity: Appears to be specific for Beclin-1.

Application Details

Application Notes: IHC, WB. Use at a dilution of 1 : 300 to 1 : 2000. The optimal dilution should be determined by the end user.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Adams, Celniker, Holt et al.: "The genome sequence of Drosophila melanogaster." in: Science (New York, N.Y.), Vol. 287, Issue 5461, pp. 2185-95, 2000 (PubMed).