Contactin 2 (Axonal) (CNTN2) antibody

Antigen: Contactin 2 (Axonal) (CNTN2)

Synonyms: AXT, TAX, TAX1, TAG-1, FLJ42746, MGC157722, DKFZp781D102, Tax, D130012K04Rik, TAG1, TAG-564, tag1, si:dz37k09.2, AXONIN-1, CNTN2, DKFZp459F1630

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350245

Additional Information

Alternative name: Contactin-2 (Axonin-1,Contactin 2, AXT, TAG1, TAX1, TAX-1)

Swiss-Prot: Q02246

Immunogen: A synthetic peptide from human contactin-2 (Axonin-1, AXT, TAG1, TAX1, TAX-1) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention. FUNCTION: May play a role in the initial growth and guidance of axons. May be involved in cell adhesion. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Note: Attached to the neuronal membrane by a GPI-anchor and is also released from neurons. Also known as: Axonin-1, Axonal glycoprotein TAG-1, Transient axonal glycoprotein 1, TAX-1, CNTN2, AXT, TAG1, TAX1, MGC157722, DKFZp781D102.

Specificity: Appears to be specific for contactin-2.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Tsiotra, Karagogeos, Theodorakis et al.: "Isolation of the cDNA and chromosomal localization of the gene (TAX1) encoding the human axonal glycoprotein TAG-1." in: Genomics, Vol. 18, Issue 3, pp. 562-7, 1994 (PubMed).

Hasler, Rader, Stoeckli et al.: "cDNA cloning, structural features, and eucaryotic expression of human TAG-1/axonin-1." in: European journal of biochemistry / FEBS, Vol. 211, Issue 1-2, pp. 329-39, 1993 (PubMed).

Kozlov, Giger, Hasler et al.: "The human TAX1 gene encoding the axon-associated cell adhesion molecule TAG-1/axonin-1: genomic structure and basic promoter." in: Genomics, Vol. 30, Issue 2, pp. 141-8, 1996 (PubMed).

Zhang, Henzel: "Signal peptide prediction based on analysis of experimentally verified cleavage sites." in: Protein science : a publication of the Protein Society, Vol. 13, Issue 10, pp. 2819-24, 2004 (PubMed).

Liu, Qian, Gritsenko et al.: "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." in: Journal of proteome research, Vol. 4, Issue 6, pp. 2070-80, 2005 (PubMed).

Gregory, Barlow, McLay et al.: "The DNA sequence and biological annotation of human chromosome 1." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006 (PubMed).