Contactin 4 (CNTN4) antibody

Details for Product No. ABIN350249
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Antigen
Synonyms MGC84491, zgc:153573, axcam, big-2, cntn4a, AXCAM, BIG-2, 9630050B05, Axcam, Big-2, FAR-1
Reactivity
Human
(26), (25), (23), (13), (12)
Host
Rabbit
(26), (2), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(14), (12), (10), (10), (4), (3), (3), (1)
Pubmed 7 references available
Quantity 100 µL
Options
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Catalog No. ABIN350249
454.67 $
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Immunogen A synthetic peptide from human Contactin-4 (AXCAM, contactin 4, BIG-2, SCA16, CNTN4A) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for contactin-4.
Purification Whole serum
Alternative Name Contactin 4
Background The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Function:Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.
Subcellular location: Cell membrane, Lipid-anchor, GPI-anchor. Secreted.
Tissue specificity: Mainly expressed in brain. Highly expressed in cerebellum and weakly expressed in corpus callosum, caudate nucleus, amygdala and spinal cord. Also expressed in testis, pancreas, thyroid, uterus, small intestine and kidney. Not expressed in skeletal muscle. Isoform 2 is weakly expressed in cerebral cortex. Also known as: Brain-derived immunoglobulin superfamily protein 2, AXCAM,Contactin 4, BIG-2, SCA16, CNTN4A, MGC33615.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Kamei, Takeda, Teramoto et al.: "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members." in: Genomics, Vol. 69, Issue 1, pp. 113-9, 2000 (PubMed).

Zeng, Zhang, Xu et al.: "A novel splice variant of the cell adhesion molecule contactin 4 ( CNTN4) is mainly expressed in human brain." in: Journal of human genetics, Vol. 47, Issue 9, pp. 497-9, 2002 (PubMed).

Hansford, Smith, Haber et al.: "Cloning and characterization of the human neural cell adhesion molecule, CNTN4 (alias BIG-2)." in: Cytogenetic and genome research, Vol. 101, Issue 1, pp. 17-23, 2003 (PubMed).

Fernandez, Morgan, Davis et al.: "Disruption of contactin 4 (CNTN4) results in developmental delay and other features of 3p deletion syndrome." in: American journal of human genetics, Vol. 74, Issue 6, pp. 1286-93, 2004 (PubMed).

Liu, Qian, Gritsenko et al.: "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." in: Journal of proteome research, Vol. 4, Issue 6, pp. 2070-80, 2005 (PubMed).

Sjöblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers. ..." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).

Miura, Shibata, Furuya et al.: "The contactin 4 gene locus at 3p26 is a candidate gene of SCA16." in: Neurology, Vol. 67, Issue 7, pp. 1236-41, 2006 (PubMed).

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