Contactin 5 (CNTN5) (N-Term) antibody

Antigen: Contactin 5 (CNTN5)

Synonyms: NB-2, HNB-2s, MGC163491, Gm507, 6720426O10Rik, A830025P08Rik, Nb-2, cntn5, fi09g01, wu:fi09g01, FAR-2, MGC151600

Epitope: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350253

Additional Information

Alternative name: Contactin-5 (NB-2, hNB-2, HNB-2s,Contactin 5, CNTN5)

Swiss-Prot: O94779

Immunogen: A synthetic peptide as a part of human contactin-5 (NB-2, hNB-2, HNB-2s, contactin 5, CNTN5) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. FUNCTION:Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. Probably involved in neuronal activity in the auditory system. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. TISSUE SPECIFICITY: Expressed in brain and kidney and at very low level in placenta. Not expressed in other tissues. In brain, it is highly expressed in the occipital lobe, amygdala, cerebral cortex, frontal lobe, thalamus and temporal lobe. Expressed at moderate level in the cerebellum, substantia nigra, putamen, medulla and hippocampus. Weakly expressed in the spinal cord and caudate nucleus. Weakly or not expressed in the corpus callosum. Also known as:Contactin 5, Neural recognition molecule NB-2, NB-2, hNB-2, HNB-2s, CNTN5.

Specificity: Appears to be specific for contactin-5.

Application Details

Application Notes: IHC, WB (confirmed with recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Kamei, Takeda, Teramoto et al.: "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members." in: Genomics, Vol. 69, Issue 1, pp. 113-9, 2000 (PubMed).