Contactin 6 (CNTN6) (internal N-Term) antibody

Antigen: Contactin 6 (CNTN6)

Synonyms: NB3, MGC133256, NB-3, DKFZp459A015

Epitope: internal N-Term

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350254

Additional Information

Alternative name: Contactin-6 (NB3,Contactin 6, CNTN6) (internal region)

Swiss-Prot: P97528

Immunogen: A synthetic peptide as a part of rat, mouse contactin-6 (NB3, contactin 6, CNTN6) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. FUNCTION:Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. TISSUE SPECIFICITY: Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord. Also known as: Neural recognition molecule NB-3, NB3,Contactin 6, CNTN6.

Specificity: Appears to be specific for contactin-6.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Publications: Ogawa, Kaneko, Masuda et al.: "Novel neural adhesion molecules in the Contactin/F3 subgroup of the immunoglobulin superfamily: isolation and characterization of cDNAs from rat brain." in: Neuroscience letters, Vol. 218, Issue 3, pp. 173-6, 1997 (PubMed).

Takeda, Akasaka, Lee et al.: "Impaired motor coordination in mice lacking neural recognition molecule NB-3 of the contactin/F3 subgroup." in: Journal of neurobiology, Vol. 56, Issue 3, pp. 252-65, 2003 (PubMed).

Cui, Hu, Tekaya et al.: "NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes." in: The Journal of biological chemistry, Vol. 279, Issue 24, pp. 25858-65, 2004 (PubMed).