Contactin-6 (NB3,Contactin 6, CNTN6) (C- or N-Term) antibody

Antigen: Contactin-6 (NB3,Contactin 6, CNTN6)

Binding Site: C- or N-Term

Clonality: Polyclonal

Host: Rabbit

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350255

Additional Information

UniProt: Q9UQ52

Immunogen: A synthetic peptide as a part of human contactin-6 (NB3, contactin 6, CNTN6) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Description: The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. FUNCTION:Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. TISSUE SPECIFICITY: Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord. Also known as: Neural recognition molecule NB-3, NB3,Contactin 6, CNTN6.

Specificity: Appears to be specific for contactin-6.

Application Details

Application Notes: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Purity: whole serum

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Kamei, Tsutsumi, Taketani et al.: "cDNA cloning and chromosomal localization of neural adhesion molecule NB-3 in human." in: Journal of neuroscience research, Vol. 51, Issue 3, pp. 275-83, 1998 (PubMed).

Sjöblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).