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Details for Product No. ABIN350259

CAMP Responsive Element Modulator (CREM) antibody

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Synonyms CREM-2, ICER, hCREM-2, ICERI, Icer, CREM
»Alternatives Mouse (Murine)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350259
Quantity 100 µL
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide to phospho S271 & S274 of human CREM (cAMP-responsive element modulator, Inducible cAMP early repressor, ICER) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat, mouse and dog.
Specificity Specific for KCNU1.
Purity whole serum
Alternative Name CREM (cAMP-responsive element modulator, Inducible cAMP early repressor, ICER)
Background Function: Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation.
Subunit: Binds DNA as a dimer. Interacts with FHL5.
Subcellular location: Nucleus.
Tissue specificity: Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes. Also known as: cAMP-responsive element modulator, Inducible cAMP early repressor, ICER.
UniProt O54982
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not tested in other applications. This antibody may also recognise the unphosphorylated form.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
West, Sharpe, Saunders: "Differential regulation of cyclic adenosine 3',5'-monophosphate (cAMP) response element-binding protein and cAMP response element modulator messenger ribonucleic acid transcripts by follicle-stimulating hormone and androgen in the adult rat testis." in: Biology of reproduction, Vol. 50, Issue 4, pp. 869-81, 1994 (PubMed).

Masquilier, Foulkes, Mattei et al.: "Human CREM gene: evolutionary conservation, chromosomal localization, and inducibility of the transcript." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 4, Issue 11, pp. 931-7, 1994 (PubMed).

Fujimoto, Fujisawa, Yoshida: "Novel isoforms of human cyclic AMP-responsive element modulator (hCREM) mRNA." in: Journal of biochemistry, Vol. 115, Issue 2, pp. 298-303, 1994 (PubMed).

Deloukas, Earthrowl, Grafham et al.: "The DNA sequence and comparative analysis of human chromosome 10." in: Nature, Vol. 429, Issue 6990, pp. 375-81, 2004 (PubMed).

Nagamori, Yomogida, Adams et al.: "Transcription factors, cAMP-responsive element modulator (CREM) and Tisp40, act in concert in postmeiotic transcriptional regulation." in: The Journal of biological chemistry, Vol. 281, Issue 22, pp. 15073-81, 2006 (PubMed).

Alternatives for antigen "CAMP Responsive Element Modulator (CREM)", type "Antibodies"
Hosts (46), (7), (6), (1)
Reactivities (56), (37), (36), (25), (24), (1), (1), (1)
Applications (38), (24), (20), (7), (4), (4), (3), (2), (2), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (14), (9), (3), (2), (2), (2), (2), (2), (1), (1), (1)