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CREM (cAMP-responsive element modulator, Inducible cAMP early repressor, ICER) (pSer271, pSer274) antibody
Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
|5 references available|
|Price||454.67 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 7 to 8 Business Days|
|Immunogen||A synthetic peptide to phospho S271 & S274 of human CREM (cAMP-responsive element modulator, Inducible cAMP early repressor, ICER) conjugated to an immunogenic carrier protein was used as the immunogen. The peptide is homologous in rat, mouse and dog.|
|Description||FUNCTION: Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation. SUBUNIT: Binds DNA as a dimer. Interacts with FHL5. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes. Also known as: cAMP-responsive element modulator, Inducible cAMP early repressor, ICER.|
|Specificity||Appears to be specific for CREM.|
|Application Notes||IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications. This antibody may also recognise the unphosphorylated form.|
|Storage||Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.|
|Restrictions||For Research Use only|
West, Sharpe, Saunders: "Differential regulation of cyclic adenosine 3',5'-monophosphate (cAMP) response element-binding protein and cAMP response element modulator messenger ribonucleic acid transcripts by follicle-stimulating hormone and androgen in the adult rat testis." in: Biology of reproduction, Vol. 50, Issue 4, pp. 869-81, 1994 (PubMed).
Masquilier, Foulkes, Mattei et al.: "Human CREM gene: evolutionary conservation, chromosomal localization, and inducibility of the transcript." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 4, Issue 11, pp. 931-7, 1994 (PubMed).
Fujimoto, Fujisawa, Yoshida: "Novel isoforms of human cyclic AMP-responsive element modulator (hCREM) mRNA." in: Journal of biochemistry, Vol. 115, Issue 2, pp. 298-303, 1994 (PubMed).
Deloukas, Earthrowl, Grafham et al.: "The DNA sequence and comparative analysis of human chromosome 10." in: Nature, Vol. 429, Issue 6990, pp. 375-81, 2004 (PubMed).
Nagamori, Yomogida, Adams et al.: "Transcription factors, cAMP-responsive element modulator (CREM) and Tisp40, act in concert in postmeiotic transcriptional regulation." in: The Journal of biological chemistry, Vol. 281, Issue 22, pp. 15073-81, 2006 (PubMed).