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Details for Product No. ABIN350261

Dihydropyrimidinase-Like 2 (DPYSL2) (pThr514), (Ser518) antibody

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Synonyms crmp2, dhprp2, drp-2, drp2, unc-33, unc33, CRMP-2, CRMP2, dpysl2, DHPRP2, DRP-2, DRP2, N2A3, ULIP-2, ULIP2, TOAD-64, Crmp2, CRMP2A, CRMP 2, PCRMP 2, PCRMP-2, PCRMP2, PfCRMP 2, PfCRMP-2
»Alternatives pThr514, Ser518
»Alternatives Human, Rat (Rattus), Mouse (Murine), Chicken
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 8 references available
Catalog no. ABIN350261
Quantity 100 µL
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from the phosphorylated sites of human T514 & S518 of CRMP-2 (DPYSL2, CRMP2, Dihydropyrimidinase-related protein 2) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat, mouse and chicken.
Specificity Appears to be specific for CRMP2.
Purity whole serum
Alternative Name CRMP-2 (Dihydropyrimidinase-related protein 2)
Background Function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.
Subunit: Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4.
Subcellular location: Cytoplasm.
Tissue specificity: Ubiquitous. Also known as: Dihydropyrimidinase-related protein 2, DRP-2, Collapsin response mediator protein 2, N2A3, DPYSL2, CRMP2.
UniProt Q16555
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. This antibody recognises mainly phospho T514S518 of CRMP-2 (but also it is quite likely to recognise the unphosphorylated form).
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Goshima, Nakamura, Strittmatter et al.: "Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33." in: Nature, Vol. 376, Issue 6540, pp. 509-14, 1995 (PubMed).

Hamajima, Matsuda, Sakata et al.: "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution." in: Gene, Vol. 180, Issue 1-2, pp. 157-63, 1997 (PubMed).

Kitamura, Takayama, Hamajima et al.: "Characterization of the human dihydropyrimidinase-related protein 2 (DRP-2) gene." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 6, Issue 5, pp. 291-7, 2000 (PubMed).

Gu, Hamajima, Ihara: "Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522." in: Biochemistry, Vol. 39, Issue 15, pp. 4267-75, 2000 (PubMed).

Inagaki, Chihara, Arimura et al.: "CRMP-2 induces axons in cultured hippocampal neurons." in: Nature neuroscience, Vol. 4, Issue 8, pp. 781-2, 2001 (PubMed).

Sjöblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).

Beausoleil, Villén, Gerber et al.: "A probability-based approach for high-throughput protein phosphorylation analysis and site localization." in: Nature biotechnology, Vol. 24, Issue 10, pp. 1285-92, 2006 (PubMed).

Stenmark, Ogg, Flodin et al.: "The structure of human collapsin response mediator protein 2, a regulator of axonal growth." in: Journal of neurochemistry, Vol. 101, Issue 4, pp. 906-17, 2007 (PubMed).

Alternatives for antigen "Dihydropyrimidinase-Like 2 (DPYSL2)", type "Antibodies"
Hosts (71), (15), (5), (2)
Reactivities (86), (65), (64), (39), (37), (25), (24), (1), (1)
Applications (64), (42), (30), (24), (16), (7), (5), (5), (2)
Conjugates (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (28), (14), (14), (8), (3), (2), (2), (1), (1), (1), (1), (1)