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Details for Product No. ABIN350278

Autophagy Related 4D, Cysteine Peptidase (ATG4D) antibody

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Antigen
Synonyms apg4d, APG4D, AUTL4, APG4-D, 9830134P12Rik, Apg4d, Atg4dl, Autl4
Reactivity
»Alternatives Human, Monkey
Host
»Alternatives Sheep
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN350278
Quantity 150 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide as a part of human, monkey cysteine protease ATG4D (autophagin-4, ATG4D, APG4D, AUTL4) conjugated to an immunogenic carrier protein has been used as the immunogen.
Specificity Appears to be specific for ATG4D.
Purity whole serum
Alternative Name cysteine protease ATG4D (autophagin-4, ATG4D, APG4D, AUTL4)
Background Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly.autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels ofautophagy have been described in some malignant tumors, and a role forautophagy in controlling the unregulated cell growth linked to cancer has been proposed. The encoded protein is also designated as a member of the C-54 family of cysteine proteases.
Function: Cysteine protease required forautophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.
Enzyme regulation: Inhibited by N-ethylmaleimide
Subcellular location: Cytoplasm
Tissue specificity: Mainly expressed in skeletal muscle and, to a lower extent, in testis. Also known as: Cysteine protease ATG4D,autophagy-related protein 4 homolog D Autophagin-4,autophagy-related cysteine endopeptidase 4, AUT-like 4 cysteine endopeptidase, APG4D, AUTL4, ATG4DThis gene encodes a member of the autophagin protein family..
UniProt Q86TL0
Research Area Autophagy
Application Notes IHC, WB. Use at a dilution of 1 : 200 to 1 : 3000. The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Mariño, Uría, Puente et al.: "Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy." in: The Journal of biological chemistry, Vol. 278, Issue 6, pp. 3671-8, 2003 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Alternatives for antigen "Autophagy Related 4D, Cysteine Peptidase (ATG4D)", type "Antibodies"
Hosts (77), (6), (4), (2)
Reactivities (73), (65), (41), (39), (38), (36), (1)
Applications (48), (40), (25), (20), (13), (6), (3), (2)
Conjugates (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Epitopes (12), (12), (12), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (1)
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