Autophagy Related 4D, Cysteine Peptidase (ATG4D) antibody

Details for Product No. ABIN350278
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Synonyms apg4d, APG4D, AUTL4, APG4-D, 9830134P12Rik, Apg4d, Atg4dl, Autl4
Human, Rat (Rattus), Mouse (Murine)
(71), (60), (44), (38), (38), (36)
(75), (4), (3), (1)
(4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Immunohistochemistry (IHC), Western Blotting (WB)
(42), (40), (26), (18), (13), (4), (3)
Pubmed 2 references available
Catalog no. ABIN350278
Quantity 100 µL
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from human ATG4D (autophagin-4, ATG4D, APG4D, AUTL4) conjugated to an immunogenic carrier protein has been used as the antigen.
Isotype IgG
Specificity Specific for VAMP3.
Purification whole serum
Alternative Name cysteine protease ATG4D (autophagin-4, ATG4D, APG4D, AUTL4)
Background Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly.autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels ofautophagy have been described in some malignant tumors, and a role forautophagy in controlling the unregulated cell growth linked to cancer has been proposed. The encoded protein is also designated as a member of the C-54 family of cysteine proteases.
Function: Cysteine protease required forautophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.
Enzyme regulation: Inhibited by N-ethylmaleimide
Subcellular location: Cytoplasm
Tissue specificity: Mainly expressed in skeletal muscle and, to a lower extent, in testis. Also known as: Cysteine protease ATG4D,autophagy-related protein 4 homolog D Autophagin-4,autophagy-related cysteine endopeptidase 4, AUT-like 4 cysteine endopeptidase, APG4D, AUTL4, ATG4DThis gene encodes a member of the autophagin protein family..
UniProt P63024
Application Notes Use at a dilution of 1 : 200 to 1 : 3000.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
General Mariño, Uría, Puente et al.: "Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy." in: The Journal of biological chemistry, Vol. 278, Issue 6, pp. 3671-8, 2003 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome...." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Hosts (75), (4), (3), (1)
Reactivities (71), (60), (44), (38), (38), (36)
Applications (42), (40), (26), (18), (13), (4), (3)
Conjugates (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Epitopes (12), (12), (12), (5), (3), (3), (2), (2), (2), (2), (1), (1), (1)
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