Dynactin 1 (DCTN1) (Internal Region) antibody

Details for Product No. ABIN350279
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DAP-150, DP-150, P135, Chip150, AL022633, Glued, p150, p150, CG9206, DYNA_DROME, Dmel\\CG9206, FCP-D, Glu, P150, P150[Glued], p150/Glued, p150/glued, p150[Glued], p150[glued], t1, Dynactin-1, g ... show more
DAP-150, DP-150, P135, Chip150, AL022633, Glued, p150, p150, CG9206, DYNA_DROME, Dmel\\CG9206, FCP-D, Glu, P150, P150[Glued], p150/Glued, p150/glued, p150[Glued], p150[glued], t1, Dynactin-1, glued, DCTN1, DKFZp469C1813 show less
Internal Region
(18), (7), (5), (2), (2), (1)
Mouse (Murine), Rat (Rattus), Human
(42), (25), (24), (14), (14), (12), (5)
(32), (10), (5), (1)
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(38), (21), (12), (10), (10), (6), (3), (1), (1)
Pubmed 6 references available
Catalog no. ABIN350279
Quantity 100 µL
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from the internal region of human DCTN1 (DAP-150, DP-150, p150-glued, p135, Dynactin subunit 1) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and moue.
Specificity Specific for GARP.
Purification whole serum
Alternative Name DCTN1 (DAP-150, DP-150, Dynactin subunit 1)
Background Function: Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.
Subunit: Large macromolecular complex of at least 10 components, p150(glued) binds directly to microtubules and to cytoplasmic dynein. Interacts with the C-terminus of MAPRE1, MAPRE2 and MAPRE3.
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton.
Tissue specificity: Brain. DISEASE: Defects in DCTN1 are the cause of progressive lower motor neuron disease. PLMND is a progressive dominant disease that has no sensory symptoms. Also known as: DAP-150, DP-150, p150-glued,p135, Dynactin subunit 1, 150 kDa dynein-associated polypeptide.
UniProt Q80XL8
Research Area Neurology
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Liquid
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term.
Expiry Date 12 months
Supplier Images
anti-Dynactin 1 (DCTN1) (Internal Region) antibody WB on rat brain lysate using Rabbit antibody to internal part of DCTN1 (DAP-150, DP-150, p150-glued, p135, Dynactin subunit 1): whole serum (ABIN350279) at 1 : 500 dilution. Pre-absorption of the antibody with the immunising peptide completely abolishes the detected band.
General Holzbaur, Tokito: "Localization of the DCTN1 gene encoding p150Glued to human chromosome 2p13 by fluorescence in situ hybridization." in: Genomics, Vol. 31, Issue 3, pp. 398-9, 1997 (PubMed).

Tokito, Howland, Lee et al.: "Functionally distinct isoforms of dynactin are expressed in human neurons." in: Molecular biology of the cell, Vol. 7, Issue 8, pp. 1167-80, 1997 (PubMed).

Collin, Nishina, Marshall et al.: "Human DCTN1: genomic structure and evaluation as a candidate for Alström syndrome." in: Genomics, Vol. 53, Issue 3, pp. 359-64, 1998 (PubMed).

Tokito, Holzbaur: "The genomic structure of DCTN1, a candidate gene for limb-girdle muscular dystrophy (LGMD2B)." in: Biochimica et biophysica acta, Vol. 1442, Issue 2-3, pp. 432-6, 1998 (PubMed).

Puls, Jonnakuty, LaMonte et al.: "Mutant dynactin in motor neuron disease." in: Nature genetics, Vol. 33, Issue 4, pp. 455-6, 2003 (PubMed).

Bu, Su: "Characterization of functional domains of human EB1 family proteins." in: The Journal of biological chemistry, Vol. 278, Issue 50, pp. 49721-31, 2003 (PubMed).

Hosts (32), (10), (5), (1)
Reactivities (42), (25), (24), (14), (14), (12), (5)
Applications (38), (21), (12), (10), (10), (6), (3), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (18), (7), (5), (2), (2), (1)
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