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Dynactin 1 (DCTN1) (AA 120-170) antibody

Details for Product No. ABIN350281
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Antigen
Synonyms
CG9206, DYNA_DROME, Dmel\\CG9206, FCP-D, Glu, P150, P150[Glued], p150, p150/Glued, p150/glued, p150[Glued], p150[glued], t1, DCTN1, DKFZp469C1813, DAP-150, DP-150, P135, AL022633, Glued, p150,  ... show more
CG9206, DYNA_DROME, Dmel\\CG9206, FCP-D, Glu, P150, P150[Glued], p150, p150/Glued, p150/glued, p150[Glued], p150[glued], t1, DCTN1, DKFZp469C1813, DAP-150, DP-150, P135, AL022633, Glued, p150, Chip150, Dynactin-1, glued show less
Epitope
AA 120-170
(18), (7), (3), (3), (2), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(45), (26), (25), (14), (14), (12), (5)
Host
Sheep
(33), (10), (5), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(40), (18), (13), (10), (10), (6), (3), (3), (1)
Pubmed 6 references available
Quantity 100 µL
Options
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Catalog No. ABIN350281
454.67 $
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Immunogen A synthetic peptide from aa region 120-170 of human DCTN1 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and moue.
Specificity Specific for DCTN1.
Purification Whole serum
Alternative Name DCTN1
Background Function: Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.
Subunit: Large macromolecular complex of at least 10 components, p150(glued) binds directly to microtubules and to cytoplasmic dynein. Interacts with the C-terminus of MAPRE1, MAPRE2 and MAPRE3.
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton.
Tissue specificity: Brain. DISEASE: Defects in DCTN1 are the cause of progressive lower motor neuron disease. PLMND is a progressive dominant disease that has no sensory symptoms. Also known as: DAP-150, DP-150, p150-glued,p135, Dynactin subunit 1, 150 kDa dynein-associated polypeptide.
Research Area Signaling, Cytoskeleton
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Holzbaur, Tokito: "Localization of the DCTN1 gene encoding p150Glued to human chromosome 2p13 by fluorescence in situ hybridization." in: Genomics, Vol. 31, Issue 3, pp. 398-9, 1997 (PubMed).

Tokito, Howland, Lee et al.: "Functionally distinct isoforms of dynactin are expressed in human neurons." in: Molecular biology of the cell, Vol. 7, Issue 8, pp. 1167-80, 1997 (PubMed).

Collin, Nishina, Marshall et al.: "Human DCTN1: genomic structure and evaluation as a candidate for Alström syndrome." in: Genomics, Vol. 53, Issue 3, pp. 359-64, 1998 (PubMed).

Tokito, Holzbaur: "The genomic structure of DCTN1, a candidate gene for limb-girdle muscular dystrophy (LGMD2B)." in: Biochimica et biophysica acta, Vol. 1442, Issue 2-3, pp. 432-6, 1998 (PubMed).

Puls, Jonnakuty, LaMonte et al.: "Mutant dynactin in motor neuron disease." in: Nature genetics, Vol. 33, Issue 4, pp. 455-6, 2003 (PubMed).

Bu, Su: "Characterization of functional domains of human EB1 family proteins." in: The Journal of biological chemistry, Vol. 278, Issue 50, pp. 49721-31, 2003 (PubMed).

Validation Images
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