Dynamin 1 antibody (DNM1) (C-Term)

Details for Product anti-DNM1 Antibody No. ABIN350298, Supplier: Log in to see
Antigen
  • dnm
  • DNM1
  • Dnm1
  • dnm1
  • si:dkey-246l19.2
  • DNM
  • AI838169
  • Dnm
  • Ftfl
  • mKIAA4093
  • dynamin-1
  • dynamin 1
  • dynamin-1-like
  • dynamin 1a
  • dynamin-1-like protein
  • dynamin 1-like
  • BACOIKO008_37
  • PTRG_07818
  • PTRG_08097
  • dnm1
  • DNM1
  • Dnm1
  • LOC100199205
  • dnm1a
  • EHI_013180
  • EHI_131670
  • DNM1L
Alternatives
anti-Human Dynamin 1 antibody for Immunofluorescence (fixed cells)
Epitope
C-Term
32
25
11
3
3
3
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Mouse (Murine), Rat (Rattus), Human
141
115
109
16
11
9
4
3
2
2
2
1
1
Host
Rabbit
114
15
15
Clonality
Polyclonal
Conjugate
This Dynamin 1 antibody is un-conjugated
3
3
3
3
3
3
3
3
3
3
3
3
3
3
Application
Immunohistochemistry (IHC), Western Blotting (WB)
101
41
39
34
22
7
5
4
4
2
2
1
Options
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Immunogen A synthetic peptide from the c-terminal region of rat Dynamin 1 conjugated to an immunogenic carrier protein was used as the antigen. The antigen is homologous in human and mouse.
Specificity Specific for Dynamin 1.
Purification Whole serum
Alternative Name Dynamin 1 (DNM1 Antibody Abstract)
Background Function: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis.
Catalytic activity: GTP + H(2)O = GDP + phosphate.
Subcellular location: Cytoplasm. Cytoplasm › cytoskeleton. Also known as: Dynamin-1, D100, DNM, EC 3.6.5.5, B dynamin, DNM 1, DNM1, Dynamin, Dynamin BREDNM19, Dynamin1.
Research Area Neurology
Pathways Toll-Like Receptors Cascades, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user. Not tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Graham, Anggono, Bache, Larsen, Craft, Robinson: "The in vivo phosphorylation sites of rat brain dynamin I." in: The Journal of biological chemistry, Vol. 282, Issue 20, pp. 14695-707, 2007 (PubMed).

Reubold, Eschenburg, Becker, Leonard, Schmid, Vallee, Kull, Manstein: "Crystal structure of the GTPase domain of rat dynamin 1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 37, pp. 13093-8, 2005 (PubMed).

Cousin, Robinson: "The dephosphins: dephosphorylation by calcineurin triggers synaptic vesicle endocytosis." in: Trends in neurosciences, Vol. 24, Issue 11, pp. 659-65, 2001 (PubMed).

Ringstad, Nemoto, De Camilli: "The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 16, pp. 8569-74, 1997 (PubMed).

Obar, Collins, Hammarback, Shpetner, Vallee: "Molecular cloning of the microtubule-associated mechanochemical enzyme dynamin reveals homology with a new family of GTP-binding proteins." in: Nature, Vol. 347, Issue 6290, pp. 256-61, 1990 (PubMed).