Dynamin 1 (DNM1) (C-Term) antibody

Details for Product No. ABIN350298
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Antigen
Synonyms dnm, DNM1, Dnm1, dnm1, si:dkey-246l19.2, DNM, AI838169, Dnm, Ftfl, mKIAA4093
Epitope
C-Term
(24), (15), (4), (3), (3), (2), (2), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Human
(95), (78), (76), (41), (36), (31), (10), (1), (1)
Host
Rabbit
(82), (10), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(66), (30), (29), (25), (14), (7), (6), (5), (3)
Pubmed 5 references available
Quantity 150 µL
Options
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Catalog No. ABIN350298
454.67 $
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Immunogen A synthetic peptide from the c-terminal region of rat Dynamin 1 conjugated to an immunogenic carrier protein was used as the antigen. The antigen is homologous in human and mouse.
Specificity Specific for Dynamin 1.
Purification Whole serum
Alternative Name Dynamin 1
Background Function: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis.
Catalytic activity: GTP + H(2)O = GDP + phosphate.
Subcellular location: Cytoplasm. Cytoplasm › cytoskeleton. Also known as: Dynamin-1, D100, DNM, EC 3.6.5.5, B dynamin, DNM 1, DNM1, Dynamin, Dynamin BREDNM19, Dynamin1.
Research Area Neurology
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user. Not tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Obar, Collins, Hammarback et al.: "Molecular cloning of the microtubule-associated mechanochemical enzyme dynamin reveals homology with a new family of GTP-binding proteins." in: Nature, Vol. 347, Issue 6290, pp. 256-61, 1990 (PubMed).

Ringstad, Nemoto, De Camilli: "The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 16, pp. 8569-74, 1997 (PubMed).

Cousin, Robinson: "The dephosphins: dephosphorylation by calcineurin triggers synaptic vesicle endocytosis." in: Trends in neurosciences, Vol. 24, Issue 11, pp. 659-65, 2001 (PubMed).

Reubold, Eschenburg, Becker et al.: "Crystal structure of the GTPase domain of rat dynamin 1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 37, pp. 13093-8, 2005 (PubMed).

Graham, Anggono, Bache et al.: "The in vivo phosphorylation sites of rat brain dynamin I." in: The Journal of biological chemistry, Vol. 282, Issue 20, pp. 14695-707, 2007 (PubMed).

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