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Endothelin Receptor Type B (EDNRB) (C-Term) antibody

Details for Product No. ABIN350306, Supplier: Log in to see
Antigen
  • EDNRB
  • abcds
  • etb
  • etrb
  • hscr
  • hscr2
  • ednrb
  • ABCDS
  • ET-B
  • ET-BR
  • ETB
  • ETBR
  • ETRB
  • HSCR
  • HSCR2
  • WS4A
  • Ednra
  • Etb
  • ETR-b
  • ETb
  • Sox10m1
Epitope
C-Term
20
16
6
4
3
3
3
3
1
1
1
1
1
Reactivity
Human, Rat (Rattus), Mouse (Murine)
85
46
43
Host
Rabbit
77
13
3
1
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
2
2
2
2
2
2
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
49
28
26
22
13
10
9
7
5
3
2
1
Supplier
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Immunogen A synthetic peptide from the c-terminal of human Endothelin B receptor (EDNRB) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
Specificity Specific for EDNRB.
Purification Whole serum
Alternative Name EDNRB (EDNRB Antibody Abstract)
Background Function: Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular location: Cell membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells. Also known as: Endothelin receptor non-selective type, EDNRB, ETRB.
Application Notes A dilution of 1: 300 to 1: 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Pingault, Girard, Bondurand et al.: "SOX10 mutations in chronic intestinal pseudo-obstruction suggest a complex physiopathological mechanism." in: Human genetics, Vol. 111, Issue 2, pp. 198-206, 2002 (PubMed).

Tsutsumi, Liang, Jones: "Novel endothelin B receptor transcripts with the potential of generating a new receptor." in: Gene, Vol. 228, Issue 1-2, pp. 43-9, 1999 (PubMed).

Elshourbagy, Korman, Wu et al.: "Molecular characterization and regulation of the human endothelin receptors." in: The Journal of biological chemistry, Vol. 268, Issue 6, pp. 3873-9, 1993 (PubMed).

Nakamuta, Takayanagi, Sakai et al.: "Cloning and sequence analysis of a cDNA encoding human non-selective type of endothelin receptor." in: Biochemical and biophysical research communications, Vol. 177, Issue 1, pp. 34-9, 1991 (PubMed).

Arai, Nakao, Hosoda et al.: "[Molecular cloning of human endothelin receptors and their expression in vascular endothelial cells and smooth muscle cells]" in: Japanese circulation journal, Vol. 56 Suppl 5, pp. 1303-7, 1993 (PubMed).