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Details for Product No. ABIN350309

Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 3 (SLC1A3) (Extracellular Domain) antibody

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Antigen
Synonyms
EA6, EAAT1, GLAST, GLAST1, Gmt1, Eaat1, GLU-T, GluT-1, MGluT1, GLAST-1, AI504299, B430115D02Rik, AF001784, CG3747, Dglt-1, Dglut-1, Dmel\\CG3747, EAAT, dEAAT, dEAAT1, dEaat1, slc1a3, wu:fb98e05, wu:fd ... show more
Epitope
»Alternatives Extracellular Domain
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350309
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from extracellular domain of human Excitatory amino acid transporter 1 (EAAT1, GLAST, GLAST1) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen shares 95% identity with rat and mouse sequence.
Specificity Appears to be specific for EAAT1.
Purity whole serum
Alternative Name Excitatory amino acid transporter 1 (EAAT1, GLAST, GLAST1)
Background Function: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Defects in SLC1A3 are the cause of episodic ataxia type 6 (EA6). EA6 is characterized by episodic ataxia, seizures, migraine and alternating hemiplegia.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia. Also known as: Sodium-dependent glutamate/aspartate transporter 1, GLAST-1, Solute carrier family 1 member 3, SLC1A3, EAAT1, GLAST, GLAST1.
UniProt P43003
Application Notes IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Arriza, Fairman, Wadiche et al.: "Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 14, Issue 9, pp. 5559-69, 1994 (PubMed).

Kawakami, Tanaka, Nakayama et al.: "Cloning and expression of a human glutamate transporter." in: Biochemical and biophysical research communications, Vol. 199, Issue 1, pp. 171-6, 1994 (PubMed).

Shashidharan, Plaitakis: "Cloning and characterization of a glutamate transporter cDNA from human cerebellum." in: Biochimica et biophysica acta, Vol. 1216, Issue 1, pp. 161-4, 1993 (PubMed).

Stoffel, Sasse, Dueker et al.: "Human high affinity, Na(+)-dependent L-glutamate/L-aspartate transporter GLAST-1 (EAAT-1): gene structure and localization to chromosome 5p11-p12." in: FEBS letters, Vol. 386, Issue 2-3, pp. 189-93, 1996 (PubMed).

Dephoure, Zhou, Villén et al.: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).

Alternatives for antigen "Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 3 (SLC1A3)", type "Antibodies"
Hosts (51), (9), (4), (1)
Reactivities (46), (37), (24), (1), (1), (1)
Applications (48), (25), (13), (12), (10), (7), (6), (4), (3), (2), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (30), (4), (2), (2), (2), (1), (1), (1), (1), (1)
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