Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 3 (SLC1A3) (Extracellular Domain) antibody

Details for Product No. ABIN350309
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Antigen
Synonyms
AF001784, CG3747, Dglt-1, Dglut-1, Dmel\\CG3747, EAAT, EAAT1, dEAAT, dEAAT1, dEaat1, slc1a3, wu:fb98e05, wu:fd50b05, zgc:56661, zgc:77768, SLC1A3, GLAST, GluT-1, EA6, GLAST1, AI504299, B430115D02Rik,  ... show more
AF001784, CG3747, Dglt-1, Dglut-1, Dmel\\CG3747, EAAT, EAAT1, dEAAT, dEAAT1, dEaat1, slc1a3, wu:fb98e05, wu:fd50b05, zgc:56661, zgc:77768, SLC1A3, GLAST, GluT-1, EA6, GLAST1, AI504299, B430115D02Rik, Eaat1, GLAST-1, GLU-T, Gmt1, MGluT1 show less
Epitope
Extracellular Domain
(31), (4), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(45), (36), (22)
Host
Rabbit
(49), (9), (4), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(46), (24), (13), (10), (9), (7), (5), (4), (2), (1), (1)
Pubmed 5 references available
Quantity 100 μL
Options
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Catalog No. ABIN350309
454.67 $
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Immunogen A synthetic peptide from extracellular domain of human EAAT1 conjugated to an immunogenic carrier protein was used as the antigen. The antigen shares 95% identity with rat and mouse sequence.
Specificity Specific for EAAT1.
Purification Whole serum
Alternative Name SLC1A3
Background Function: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Defects in SLC1A3 are the cause of episodic ataxia type 6 (EA6). EA6 is characterized by episodic ataxia, seizures, migraine and alternating hemiplegia.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia. Also known as: Sodium-dependent glutamate/aspartate transporter 1, GLAST-1, Solute carrier family 1 member 3, SLC1A3, EAAT1, GLAST, GLAST1.
Application Notes A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Arriza, Fairman, Wadiche et al.: "Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 14, Issue 9, pp. 5559-69, 1994 (PubMed).

Kawakami, Tanaka, Nakayama et al.: "Cloning and expression of a human glutamate transporter." in: Biochemical and biophysical research communications, Vol. 199, Issue 1, pp. 171-6, 1994 (PubMed).

Shashidharan, Plaitakis: "Cloning and characterization of a glutamate transporter cDNA from human cerebellum." in: Biochimica et biophysica acta, Vol. 1216, Issue 1, pp. 161-4, 1993 (PubMed).

Stoffel, Sasse, Dueker et al.: "Human high affinity, Na(+)-dependent L-glutamate/L-aspartate transporter GLAST-1 (EAAT-1): gene structure and localization to chromosome 5p11-p12." in: FEBS letters, Vol. 386, Issue 2-3, pp. 189-93, 1996 (PubMed).

Dephoure, Zhou, Villén et al.: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).

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