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Fibroblast Growth Factor 2 (Basic) (FGF2) (AA 240-285) antibody

Details for Product No. ABIN350321
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Antigen
Synonyms Fgf-2, Fgfb, bFGF, FGF-2, BFGF, FGFB, HBGF-2
Epitope
AA 240-285
(6), (5), (4), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus), Mouse (Murine)
(178), (41), (30), (29), (15), (3), (2), (1), (1), (1), (1)
Host
Sheep
(110), (90), (5), (1), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(17), (7), (5), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(139), (118), (60), (28), (21), (12), (11), (10), (10), (10), (9), (6), (2), (2), (1), (1), (1), (1), (1)
Pubmed 7 references available
Quantity 150 µL
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Catalog No. ABIN350321
454.67 $
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Immunogen A synthetic peptide from aa region 240-285 of human FGF2 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in many other species including rat and mouse.
Specificity Specific for FGF2.
Purification Whole serum
Alternative Name FGF2
Background The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. Also known as: BFGF, FGFB, HBGF-2, prostatropin.
Application Notes A dilution of 1 : 300 to 1 : 4000 is recommended.
The optimal dilution should be determined by the end user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 150 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Watson, Anthony, Pickett et al.: "Reverse transcription with nested polymerase chain reaction shows expression of basic fibroblast growth factor transcripts in human granulosa and cumulus cells from in vitro fertilisation patients." in: Biochemical and biophysical research communications, Vol. 187, Issue 3, pp. 1227-31, 1992 (PubMed).

Zhu, Komiya, Chirino et al.: "Three-dimensional structures of acidic and basic fibroblast growth factors." in: Science (New York, N.Y.), Vol. 251, Issue 4989, pp. 90-3, 1991 (PubMed).

Ago, Kitagawa, Fujishima et al.: "Crystal structure of basic fibroblast growth factor at 1.6 A resolution." in: Journal of biochemistry, Vol. 110, Issue 3, pp. 360-3, 1992 (PubMed).

Prats, Kaghad, Prats et al.: "High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 6, pp. 1836-40, 1989 (PubMed).

Arkudas, Tjiawi, Bleiziffer et al.: "Fibrin gel-immobilized VEGF and bFGF efficiently stimulate angiogenesis in the AV loop model." in: Molecular medicine (Cambridge, Mass.), Vol. 13, Issue 9-10, pp. 480-7, 2007 (PubMed).

Neuzil, Swettenham, Wang et al.: "alpha-Tocopheryl succinate inhibits angiogenesis by disrupting paracrine FGF2 signalling." in: FEBS letters, Vol. 581, Issue 24, pp. 4611-5, 2007 (PubMed).

Alexander, Watt, Sawaji et al.: "Activin A is an anticatabolic autocrine cytokine in articular cartilage whose production is controlled by fibroblast growth factor 2 and NF-kappaB." in: Arthritis and rheumatism, Vol. 56, Issue 11, pp. 3715-25, 2007 (PubMed).

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